发明授权
- 专利标题： Anti-ADDL antibodies and uses thereof
- 专利标题（中）： 抗ADDL抗体及其用途
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申请号： US13368742申请日： 2012-02-08
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公开(公告)号： US08383113B2公开(公告)日： 2013-02-26
- 发明人: Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kristen Viola
- 申请人： Paul Acton , Zhiqiang An , Andrew J. Bett , Robert Breese , Lei Chang , Elizabeth Chen Dodson , Gene Kinney , William Klein , Mary P. Lambert , Xiaoping Liang , Paul Shughrue , William R. Strohl , Kristen Viola
- 申请人地址： US IL Evanston US NJ Rahway
- 专利权人： Northwestern University,Merck Sharp & Dohme Corp.
- 当前专利权人： Northwestern University,Merck Sharp & Dohme Corp.
- 当前专利权人地址： US IL Evanston US NJ Rahway
- 代理机构： Licata & Tyrrell P.C.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/18 ; G01N33/53
摘要：
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
公开/授权文献
- US20120171224A1 Anti-ADDL Antibodies and Uses Thereof 公开/授权日：2012-07-05