发明授权
US08383355B2 Combination of sPLA2 type IIA mass and OXPL/APOB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event
失效
sPLA2型IIA质量和OXPL / APOB心血管危险因素的组合用于心血管疾病/事件的诊断/预后
- 专利标题： Combination of sPLA2 type IIA mass and OXPL/APOB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event
- 专利标题（中）： sPLA2型IIA质量和OXPL / APOB心血管危险因素的组合用于心血管疾病/事件的诊断/预后
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申请号： US13498208申请日： 2009-12-08
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公开(公告)号： US08383355B2公开(公告)日： 2013-02-26
- 发明人: Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
- 申请人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
- 申请人地址： FR Paris US CA Oakland
- 专利权人： Institut National de la Sante et de la Recherche Medicale (INSERM),The Regents of the University of California
- 当前专利权人： Institut National de la Sante et de la Recherche Medicale (INSERM),The Regents of the University of California
- 当前专利权人地址： FR Paris US CA Oakland
- 代理机构： Whitham Curtis Christofferson & Cook, PC
- 优先权： WOPCT/EP2009/062852 20091002
- 国际申请： PCT/EP2009/066604 WO 20091208
- 国际公布： WO2011/038786 WO 20110407
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
The present invention related to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising: —measuring, in a sample obtained from said subject, at least two cardiovascular risk factors: a) sPLA2 type HA mass and b) oxidized phospholipids on apolipoprotein B-IOO particles (OxPL/apoB), —combining said measurements, the combined value of sPLA2 type HA mass and OxPL/apoB being indicative of having or a risk of having or developing a cardiovascular disease and/or cardiovascular event.
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