-
1.发明授权Combination of sPLA2 type IIA mass and OXPL/APOB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event 失效sPLA2型IIA质量和OXPL / APOB心血管危险因素的组合用于心血管疾病/事件的诊断/预后公开(公告)号：US08383355B2
公开(公告)日：2013-02-26
申请号：US13498208
申请日：2009-12-08
申请人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
发明人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , C12Q1/44 , G01N33/92 , G01N2333/775 , G01N2333/918 , G01N2333/92 , G01N2800/32 , G01N2800/52
摘要： The present invention related to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising: —measuring, in a sample obtained from said subject, at least two cardiovascular risk factors: a) sPLA2 type HA mass and b) oxidized phospholipids on apolipoprotein B-IOO particles (OxPL/apoB), —combining said measurements, the combined value of sPLA2 type HA mass and OxPL/apoB being indicative of having or a risk of having or developing a cardiovascular disease and/or cardiovascular event.
摘要翻译： 本发明涉及鉴定患有或有风险的患有心血管疾病和/或心血管事件的患者的方法，其包括： - 在从所述受试者获得的样品中测定至少两种心血管危险因素：a ）sPLA2型HA质量和b）载脂蛋白B-100颗粒（OxPL /载脂蛋白）上的氧化磷脂，组合所述测量，sPLA2型HA质量和OxPL / apoB的组合值表示具有或具有或发展的风险 心血管疾病和/或心血管事件。
-
2.发明授权Methods of identifying a subject having or at risk of having or developing coronary artery disease 有权确定患有或有发生冠状动脉疾病或有发展危险的受试者的方法公开(公告)号：US07939287B2
公开(公告)日：2011-05-10
申请号：US12465930
申请日：2009-05-14
申请人： Sotirios Tsimikas , Joseph Witztum
发明人： Sotirios Tsimikas , Joseph Witztum
IPC分类号： C12Q1/60
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G01N33/92 , G01N2333/92 , G01N2800/324 , Y10S514/824
摘要： Provided herein are compositions and methods for identifying individuals at risk for developing coronary artery disease (CAD).
摘要翻译： 本文提供了用于鉴定发生冠状动脉疾病（CAD）风险的个体的组合物和方法。
-
公开(公告)号：US20070122419A1
公开(公告)日：2007-05-31
申请号：US10552330
申请日：2004-04-12
IPC分类号： A61K39/09 , A61K39/00 , A61K31/739
CPC分类号： A61K31/661 , A61K31/7028 , A61K39/0012 , A61K39/092 , A61K2039/505 , C07K16/18
摘要： During the progression of atherosclerosis, autoantibodies are induced to epitopes of oxidized low-density lipoprotein (OxLDL), and active immunization of hypercholesterolemic mice with OxLDL ameliorates athero-genesis. The present studies have identified anti-OXLDL autoantibodies that share complete genetic and structural identity with antibodies produced by anti-phosphorylcholine B-cell clone, T15.
摘要翻译： 在动脉粥样硬化进程期间，自身抗体被诱导为氧化低密度脂蛋白（OxLDL）的表位，并且用OxLDL主动免疫高胆固醇血小鼠改善动脉粥样硬化。 本研究已经鉴定出与抗磷酸胆碱B细胞克隆T15产生的抗体具有完全的遗传和结构同一性的抗OXLDL自身抗体。
-
4.发明授权Combination of sPLA2 activity and oxPL/apoB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event 有权sPLA2活性与oxPL / apoB心血管危险因素的组合用于心血管疾病/事件的诊断/预后公开(公告)号：US08361732B2
公开(公告)日：2013-01-29
申请号：US13416014
申请日：2012-03-09
申请人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
发明人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/92 , G01N2333/918 , G01N2800/32 , G01N2800/50
摘要： The use of a combination of sPLA2 activity and OxPL/apoB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event or for the monitoring of a cardiovascular disease.
摘要翻译： 使用sPLA2活性和OxPL / apoB心血管危险因素的组合来诊断/预后心血管疾病/事件或监测心血管疾病。
-
公开(公告)号：US5169937A
公开(公告)日：1992-12-08
申请号：US426306
申请日：1989-10-24
IPC分类号： G01N33/72
CPC分类号： G01N33/723
摘要： Methods of preparing glucitollysine-hemoglobin from a sample of glucohemoglobin containing stable and labile glucohemoglobins and for assaying for the presence of stable glucohemoglobin are disclosed, as is a diagnostic assay system useful for carrying out the methods.
摘要翻译： 公开了从含有稳定和不稳定的葡糖血红蛋白的葡糖血红蛋白样品中测定稳定的葡糖血红蛋白的方法制备葡糖糖苷血红蛋白的方法，以及用于实施该方法的诊断测定系统。
-
6.发明申请COMBINATION OF sPLA2 TYPE IIA MASS AND OXPL/APOB CARDIOVASCULAR RISK FACTORS FOR THE DIAGNOSIS/PROGNOSIS OF A CARDIOVASCULAR DISEASE/EVENT 失效sPLA2型IIA质量和OXPL / APOB心血管危险因素的联合用于诊断/预防心血管疾病/事件公开(公告)号：US20130017557A1
公开(公告)日：2013-01-17
申请号：US13498208
申请日：2009-12-08
申请人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
发明人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
IPC分类号： G01N33/573 , C12Q1/44 , G01N27/62 , G01N33/566
CPC分类号： G01N33/6893 , C12Q1/44 , G01N33/92 , G01N2333/775 , G01N2333/918 , G01N2333/92 , G01N2800/32 , G01N2800/52
摘要： The present invention related to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising: —measuring, in a sample obtained from said subject, at least two cardiovascular risk factors: a) sPLA2 type HA mass and b) oxidized phospholipids on apolipoprotein B-IOO particles (OxPL/apoB), —combining said measurements, the combined value of sPLA2 type HA mass and OxPL/apoB being indicative of having or a risk of having or developing a cardiovascular disease and/or cardiovascular event.
摘要翻译： 本发明涉及鉴定患有或有风险的患有心血管疾病和/或心血管事件的患者的方法，其包括： - 在从所述受试者获得的样品中测定至少两种心血管危险因素：a ）sPLA2型HA质量和b）载脂蛋白B-100颗粒（OxPL /载脂蛋白）上的氧化磷脂，组合所述测量，sPLA2型HA质量和OxPL / apoB的组合值表示具有或具有或发展的风险 心血管疾病和/或心血管事件。
-
7.发明申请PHOSPHOLIPID OXIDATION AND Lp-PLA2 AS PREDICTORS OF CORONARY ARTERY DISEASE 有权磷酸化氧化和Lp-PLA2作为冠状动脉疾病的预防因素公开(公告)号：US20090317819A1
公开(公告)日：2009-12-24
申请号：US12465930
申请日：2009-05-14
申请人： Sotirios Tsimikas , Joseph Witztum
发明人： Sotirios Tsimikas , Joseph Witztum
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G01N33/92 , G01N2333/92 , G01N2800/324 , Y10S514/824
摘要： Provided herein are compositions and methods for identifying individuals at risk for developing coronary artery disease (CAD).
摘要翻译： 本文提供了用于鉴定发生冠状动脉疾病（CAD）风险的个体的组合物和方法。
-
8.发明申请Methods for assessing atherogenesis by determining oxidized phospholipid to apolipoprotein B ratios 有权通过测定氧化磷脂对载脂蛋白B的比例来评估动脉粥样化形成的方法公开(公告)号：US20060177435A1
公开(公告)日：2006-08-10
申请号：US11244300
申请日：2005-10-05
申请人： Sotirios Tsimikas , Joseph Witztum
发明人： Sotirios Tsimikas , Joseph Witztum
IPC分类号： A61K39/395 , G01N33/53
CPC分类号： G01N33/5308 , G01N33/92 , G01N2333/775 , G01N2800/32 , G01N2800/323
摘要： The present invention relates to the analysis of oxidized phospholipids (OxPL) on apolipoprotein B-100 in patients at high risk or with documented coronary artery disease (CAD) or acute coronary syndromes (ACS) such as unstable angina and acute myocardial infarction or suspected of being at risk for ACS. Such methods are useful for diagnostic purposes and for monitoring the effects of dietary interventions or with drugs such as statins. More particularly, the present invention relates to methods for determining OxPL/apoB ratios as indices of atherosclerosis regression and plaque stability.
摘要翻译： 本发明涉及高风险患者或记录冠状动脉疾病（CAD）或急性冠状动脉综合征（ACS）如不稳定性心绞痛和急性心肌梗死的患者载脂蛋白B-100上的氧化磷脂（OxPL）的分析或怀疑 有ACS的风险。 这些方法对于诊断目的和监测饮食干预措施或药物如他汀类药物的作用是有用的。 更具体地说，本发明涉及用于确定OxPL / apoB比值作为动脉粥样硬化消退指数和斑块稳定性的方法。
-
9.发明授权
公开(公告)号：US4876188A
公开(公告)日：1989-10-24
申请号：US932442
申请日：1986-11-18
CPC分类号： G01N33/723 , Y10S436/808 , Y10S436/811 , Y10S436/815 , Y10S436/825
摘要： Methods of preparing glucitollysinehemoglobin from a sample of glucohemoglobin containing stable and labile glucohemoglobins and for assaying for the presence of stable glucohemoglobin are disclosed, as is a diagnostic assay system useful for carrying out the methods.
-
10.发明申请COMBINATION OF SPLA2 ACTIVITY AND OXPL/APOB CARDIOVASCULAR RISK FACTORS FOR THE DIAGNOSIS/PROGNOSIS OF A CARDIOVASCULAR DISEASE/EVENT 有权SPLA2活性与OXPL / APOB心血管危险因素的联合用于心血管疾病/事件的诊断/预防公开(公告)号：US20120171705A1
公开(公告)日：2012-07-05
申请号：US13416014
申请日：2012-03-09
申请人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
发明人： Ziad Mallat , Alain Tedgui , Sotirios Tsimikas , Joseph Witztum
IPC分类号： G01N33/566
CPC分类号： G01N33/6893 , G01N33/92 , G01N2333/918 , G01N2800/32 , G01N2800/50
摘要： The use of a combination of sPLA2 activity and OxPL/apoB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event or for the monitoring of a cardiovascular disease.
摘要翻译： 使用sPLA2活性和OxPL / apoB心血管危险因素的组合来诊断/预后心血管疾病/事件或监测心血管疾病。
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.017 秒)
