Techniques to detect for end of service using dynamic inactivity timer thresholds are described. An access terminal establishes a radio connection for one or more applications. Data and signaling for the application(s) may be sent on one or more first flows (e.g., RLP flows) that may carry any number of second flows (e.g., IP flows). The access terminal determines a dynamic inactivity timer threshold for each first flow, e.g., based on at least one inactivity timer threshold for at least one second flow mapped to that first flow. The access terminal determines whether each first flow is inactive based on the inactivity timer threshold for that first flow, e.g., declares each first flow to be inactive if no activity is detected on that first flow for a period exceeding the inactivity timer threshold. The access terminal closes the radio connection when all first flow(s) are determined to be inactive.