发明授权
US08388953B2 Method of increasing cathepsin B-induced cleavage of amyloid-β peptides
有权
增加组织蛋白酶B诱导的淀粉样蛋白的切割的方法 肽
- 专利标题： Method of increasing cathepsin B-induced cleavage of amyloid-β peptides
- 专利标题（中）： 增加组织蛋白酶B诱导的淀粉样蛋白的切割的方法 肽
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申请号： US12826403申请日： 2010-06-29
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公开(公告)号： US08388953B2公开(公告)日： 2013-03-05
- 发明人: Li Gan , Lennart Mucke , Erik Roberson , Sarah Mueller-Steiner
- 申请人： Li Gan , Lennart Mucke , Erik Roberson , Sarah Mueller-Steiner
- 申请人地址： US CA San Francisco
- 专利权人： The J. David Gladstone Institutes
- 当前专利权人： The J. David Gladstone Institutes
- 当前专利权人地址： US CA San Francisco
- 代理机构： Bozicevic, Field & Francis LLP.
- 代理商 Paula A. Borden
- 主分类号： A61K38/43
- IPC分类号： A61K38/43
摘要：
The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor; as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.
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