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发明授权
US08394742B2 Methods, compounds and compositions with genotype selective anticancer activity 有权
具有基因型选择性抗癌活性的方法，化合物和组合物

Methods, compounds and compositions with genotype selective anticancer activity
摘要：
This invention is directed to methods for screening and identification of compounds capable of selectively eliminating cancer cells with specific loss-of-function alterations, including but not limited to mutations, deletions, hypermethylations, and other types of gene silencing. This invention is also directed to novel compounds that selectively eliminate cancer cells with specific loss-of-function alterations. Furthermore, this invention is directed to methods for production and therapeutic use of compounds that selectively eliminate cancer cells with specific loss-of-function alterations.
摘要（中）：

本发明涉及用于筛选和鉴定能够以特定功能丧失功能改变选择性地除去癌细胞的化合物的方法，包括但不限于突变，缺失，高甲基化和其他类型的基因沉默。 本发明还涉及以特定的功能丧失改变选择性地消除癌细胞的新型化合物。 此外，本发明涉及用于特异性功能丧失改变选择性地消除癌细胞的化合物的生产和治疗用途的方法。

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