A method is provided that includes acquiring a first set of image data from X-rays produced at a first energy level and a second set of image data from X-rays produced at a second energy level. The method includes generating a first noise mask for a first basis material and a second noise mask for a second basis material and removing pixels corresponding to cross contaminating structural information from the first noise mask and the second noise mask. The method includes processing a first materially decomposed image generated from the first set of image data and the second set of digital data using the second noise mask after removal of the cross contaminating structural information and processing a second MD image generated from the first set of image data and the second set of digital data using the first noise mask after removal of the cross contaminating structural information.