An arrangement and method for reducing the nitrogen oxide content in the exhaust gas of an internal combustion engine with the aid of ammonia and/or ammonia-releasing reduction agents, whereby ammonia and/or ammonia-containing reduction agent is added to the exhaust gas stream upstream of a catalyst combination composed of an SCR catalyst and a subsequent NH3-oxidation catalyst in such a way that a homogeneous mixture of exhaust gas and ammonia is present upstream of the SCR catalyst. To optimize the reaction or conversion of nitrogen oxides, disposed downstream of the combination of a first SCR catalyst and a first NH3-oxidation catalyst is at least one second catalyst having SCR activity in order in this way to reduce the nitrogen oxides formed at the first NH3-oxidation catalyst due to insufficient selectivity of the catalyst to nitrogen with not yet oxidized NH3.