发明授权
US08409566B2 Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis
失效
基于CXCR-4基因在肿瘤发生中的作用的治疗和诊断应用
- 专利标题： Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis
- 专利标题（中）： 基于CXCR-4基因在肿瘤发生中的作用的治疗和诊断应用
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申请号： US12367308申请日： 2009-02-06
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公开(公告)号： US08409566B2公开(公告)日： 2013-04-02
- 发明人: Gerald P. Murphy , Alton L. Boynton , Anil Sehgal
- 申请人： Alton L. Boynton , Anil Sehgal , Bridgette Murphy
- 申请人地址： US MD Bethesda
- 专利权人： Northwest Biotherapeutics, Inc.
- 当前专利权人： Northwest Biotherapeutics, Inc.
- 当前专利权人地址： US MD Bethesda
- 代理机构： Christensen O'Connor Johnson Kindness PLLC
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K35/12
摘要：
The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicant's surprising discovery that the inhibition of CXCR-4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.
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