发明授权
- 专利标题： Anti-ADDL monoclonal antibody and use thereof
- 专利标题（中）： 抗ADDL单克隆抗体及其用途
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申请号： US13361143申请日： 2012-01-30
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公开(公告)号： US08420093B2公开(公告)日： 2013-04-16
- 发明人: Gene Kinney , William R. Strohl , Zhiqiang An
- 申请人： Gene Kinney , William R. Strohl , Zhiqiang An
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理机构： Licata & Tyrrell P.C.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The present invention relates to antibodies that differentially recognize multi-dimensional conformations of Aβ-derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid β 1-42.
公开/授权文献
- US20120164158A1 Anti-ADDL Monoclonal Antibody and Use Thereof 公开/授权日：2012-06-28
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