发明授权
- 专利标题： Drug composition for treating tumor with polymeric micelle encapsulating anti-neoplastic
- 专利标题（中）： 用聚合胶束包封抗肿瘤剂治疗肿瘤的药物组合物
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申请号： US13265802申请日： 2009-08-20
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公开(公告)号： US08420119B2公开(公告)日： 2013-04-16
- 发明人: Yuan-Hung Hsu , Chu-Chun Hsueh , Yuan-Chia Chang , Jui-Mei Lu , Pei Kan
- 申请人： Yuan-Hung Hsu , Chu-Chun Hsueh , Yuan-Chia Chang , Jui-Mei Lu , Pei Kan
- 申请人地址： TW Hsinchu
- 专利权人： Industrial Technology Research Institute
- 当前专利权人： Industrial Technology Research Institute
- 当前专利权人地址： TW Hsinchu
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： CN200910132138 20090421
- 国际申请： PCT/CN2009/073382 WO 20090820
- 国际公布： WO2010/121455 WO 20101028
- 主分类号： A61K9/14
- IPC分类号： A61K9/14 ; A61K9/51 ; A61K31/44 ; A01N43/42
摘要：
This present disclosure relates to pharmaceutical compositions for treating tumors using a polymeric micelle encapsulating an anti-tumor drug. The polymeric micelle comprises block copolymers comprising at least one hydrophilic block, at least one hydrophobic block, and at least one zwitterion. The present disclosure also relates to methods of enhancing the solubility of such drugs, methods of increasing the blood circulating time of such drugs, and methods of delivering such drugs to one or more solid tumors.
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