Systems and methods of resistance-based memory circuit parameter adjustment are disclosed. In a particular embodiment, a method of determining a set of parameters of a resistance-based memory circuit includes determining a range of sizes for a clamp transistor and selecting a set of clamp transistors having sizes within the determined range of sizes. For each clamp transistor in the set of clamp transistors, a simulation may be executed to generate a first contour graph representing current values over a range of statistical values. The first contour graph may be used to identify a read disturbance area and a design range of the gate voltage of the clamp transistor and a load of the clamp transistor. The method may execute a simulation to generate a second contour graph representing sense margin over a range of statistical values of the gate voltage of the clamp transistor and the load of the clamp transistor. A sense margin may be selected based on the second contour graph that also satisfies the design range of the first contour graph. A sense margin may be determined for a selected clamp transistor in the set of transistors and the corresponding gate voltage and the load of the selected clamp transistor is determined based on the determined sense margin.