发明授权
- 专利标题： Monoclonal antibodies against claudin-18 for treatment of cancer
- 专利标题（中）： 用于治疗癌症的克劳丁-18单克隆抗体
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申请号： US12601488申请日： 2008-05-27
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公开(公告)号： US08425902B2公开(公告)日： 2013-04-23
- 发明人: Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
- 申请人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
- 申请人地址： DE Mainz DE Mainz
- 专利权人： Ganymed Pharmaceuticals AG,Johannes Gutenberg-Universitat
- 当前专利权人： Ganymed Pharmaceuticals AG,Johannes Gutenberg-Universitat
- 当前专利权人地址： DE Mainz DE Mainz
- 代理机构： McAndrews, Held & Malloy Ltd.
- 优先权： EP07010622 20070529
- 国际申请： PCT/EP2008/004197 WO 20080527
- 国际公布： WO2008/145338 WO 20081204
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.