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公开(公告)号：US08425902B2
公开(公告)日：2013-04-23
申请号：US12601488
申请日：2008-05-27
申请人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
发明人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症，胆囊癌及其转移灶。
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公开(公告)号：US09212228B2
公开(公告)日：2015-12-15
申请号：US13425538
申请日：2012-03-21
申请人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Phillippe Thiel
发明人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Phillippe Thiel
IPC分类号： C07K16/00 , A61K39/395 , C07K16/30 , A61K47/48 , A61K51/10
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症和胆囊癌。
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公开(公告)号：US08168427B2
公开(公告)日：2012-05-01
申请号：US12094530
申请日：2006-11-24
申请人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Cristoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Philippe Thiel
发明人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Cristoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Philippe Thiel
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症和胆囊癌。
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4.发明申请公开(公告)号：US20100166779A1
公开(公告)日：2010-07-01
申请号：US12601488
申请日：2008-05-27
申请人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
发明人： Ugur Sahin , Ozlem Tureci , Gunda Brandenburg , Dirk Usener
IPC分类号： A61K39/395 , C07K16/00 , C07K16/30 , C12N5/00 , A61P35/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD1 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, cancer of the gallbladder, and the metastases thereof.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌， 头颈癌，胆囊癌及其转移灶。
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公开(公告)号：US20090169547A1
公开(公告)日：2009-07-02
申请号：US12094530
申请日：2006-11-24
申请人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Cristoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Philippe Thiel
发明人： Ugur Sahin , Ozlem Tureci , Dirk Usener , Stefan Fritz , Cristoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schroder , Philippe Thiel
IPC分类号： A61K39/395 , C07K16/30 , C12N5/16 , A61P35/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症和胆囊癌。
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公开(公告)号：US09499609B2
公开(公告)日：2016-11-22
申请号：US13306545
申请日：2011-11-29
申请人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
发明人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
IPC分类号： C07K16/00 , A61K39/395 , C07K16/18 , A61K47/48 , A61K51/10 , C07K16/30 , A61K45/06 , A61K39/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD1 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌， 头颈癌，胆囊癌。
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7.发明申请公开(公告)号：US20120195830A1
公开(公告)日：2012-08-02
申请号：US13425538
申请日：2012-03-21
申请人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
发明人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
IPC分类号： A61K51/10 , A61P35/00 , A61K39/395 , C07K16/30 , C12N5/16
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌，头部 - 癌症和胆囊癌。
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公开(公告)号：US20120164160A1
公开(公告)日：2012-06-28
申请号：US13306545
申请日：2011-11-29
申请人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
发明人： Ugur Sahin , Özlem Türeci , Dirk Usener , Stefan Fritz , Christoph Uherek , Gunda Brandenburg , Harald-Gerhard Geppert , Anja Kristina Schröder , Phillippe Thiel
IPC分类号： C07K16/30 , C12N5/00 , C12N5/16 , A61P35/04 , A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6807 , A61K47/6809 , A61K47/6813 , A61K47/6821 , A61K47/6823 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K51/1063 , A61K2039/505 , C07K16/28 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD1 8, including tumor-related diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLD18的细胞相关疾病的治疗剂的抗体，包括肿瘤相关疾病如胃癌，食管癌，胰腺癌，肺癌，卵巢癌，结肠癌，肝癌， 头颈癌，胆囊癌。
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