发明授权
US08426581B2 RNA interference mediated inhibition of the FCεR1α gene
有权
RNA干扰介导的FCepsilonR1alpha基因的抑制
- 专利标题： RNA interference mediated inhibition of the FCεR1α gene
- 专利标题（中）： RNA干扰介导的FCepsilonR1alpha基因的抑制
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申请号： US13256095申请日： 2010-03-25
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公开(公告)号： US08426581B2公开(公告)日： 2013-04-23
- 发明人: Vasant Jadhav , Victoria Pickering , Walter Strapps
- 申请人： Vasant Jadhav , Victoria Pickering , Walter Strapps
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Peter Haeberli; David A. Muthard
- 国际申请： PCT/US2010/028687 WO 20100325
- 国际公布： WO2010/111503 WO 20100930
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12N15/11
摘要：
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of FCεR1α gene expression and/or activity, and/or modulate a FCεR1α gene expression pathway. Specifically, the invention relates to doublestranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against FCεR1α gene expression.
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