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1.发明申请RNA Interference Mediated Inhibition of the Intercellular Adhesion Molecule 1 (ICAM-1) Gene Expression Using Short Interfering Nucleic Acid (siNA) 审中-公开RNA干扰介导的使用短干扰核酸（siNA）的细胞间粘附分子1（ICAM-1）基因表达的抑制公开(公告)号：US20120004282A1
公开(公告)日：2012-01-05
申请号：US13256170
申请日：2010-03-25
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of ICAM-1 gene expression and/or activity, and/or modulate a ICAM-1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against ICAM-1 gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗响应于ICAM-1基因表达和/或活性的调节和/或调节ICAM-1基因的性状，疾病和病症的化合物，组合物和方法 表达途径。 具体地说，本发明涉及包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）等双链核酸分子， 和能够介导或介导针对ICAM-1基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。
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公开(公告)号：US20120077706A1
公开(公告)日：2012-03-29
申请号：US13212965
申请日：2011-08-18
申请人： Kevin J. LEE , Richard Axel , Walter Strapps , Gilad Barnea
发明人： Kevin J. LEE , Richard Axel , Walter Strapps , Gilad Barnea
IPC分类号： C12Q1/02 , C12N15/62 , C12N15/63 , C40B30/08 , C12N9/96 , C12N5/10 , C12Q1/34 , C12N1/21 , C07K14/00
CPC分类号： G01N33/6845 , C12N15/1055 , G01N33/9406 , G01N2333/726 , G01N2500/10
摘要： The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
摘要翻译： 本发明涉及一种用于确定测试化合物或化合物混合物是否调节两种感兴趣的蛋白质之间的相互作用的方法。 通过使用两个重组分子，其中之一含有蛋白水解分子的切割位点和基因的活化剂，其中之一含有第一个蛋白质，可以进行测定。 第二重组分子包括第二蛋白质和蛋白水解分子。 如果测试化合物与第一种蛋白质结合，则开始反应，由此活化剂被切割，并激活报告基因。
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公开(公告)号：US20060147975A1
公开(公告)日：2006-07-06
申请号：US11346759
申请日：2006-02-02
申请人： Kevin Lee , Richard Axel , Walter Strapps , Gilad Barnea
发明人： Kevin Lee , Richard Axel , Walter Strapps , Gilad Barnea
CPC分类号： G01N33/6845 , C12N15/1055 , G01N33/9406 , G01N2333/726 , G01N2500/10
摘要： The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
摘要翻译： 本发明涉及一种用于确定测试化合物或化合物混合物是否调节两种感兴趣的蛋白质之间的相互作用的方法。 通过使用两个重组分子，其中之一含有蛋白水解分子的切割位点和基因的活化剂，其中之一含有第一个蛋白质，可以进行测定。 第二重组分子包括第二蛋白质和蛋白水解分子。 如果测试化合物与第一种蛋白质结合，则开始反应，由此活化剂被切割，并激活报告基因。
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公开(公告)号：US20050100934A1
公开(公告)日：2005-05-12
申请号：US10888313
申请日：2004-07-09
申请人： Kevin Lee , Richard Axel , Walter Strapps , Gilad Barnea
发明人： Kevin Lee , Richard Axel , Walter Strapps , Gilad Barnea
CPC分类号： G01N33/6845 , C12N15/1055 , G01N33/9406 , G01N2333/726 , G01N2500/10
摘要： The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
摘要翻译： 本发明涉及一种用于确定测试化合物或化合物混合物是否调节两种感兴趣的蛋白质之间的相互作用的方法。 通过使用两个重组分子，其中之一含有蛋白水解分子的切割位点和基因的活化剂，其中之一含有第一个蛋白质，可以进行测定。 第二重组分子包括第二蛋白质和蛋白水解分子。 如果测试化合物与第一种蛋白质结合，则开始反应，由此活化剂被切割，并激活报告基因。
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5.发明申请RNA Interference Mediated Inhibition of Signal Transducer and Activator of Transcription 1 (STAT1) Gene Expression Using Short Interfering Nucleic Acid (siNA) 审中-公开RNA干扰介导的使用短干扰核酸（siNA）的信号转导和转录激活因子1（STAT1）基因表达的抑制作用公开(公告)号：US20120022142A1
公开(公告)日：2012-01-26
申请号：US13256146
申请日：2010-03-25
IPC分类号： A61K31/713 , A61P11/14 , A61P11/06 , C07H21/02 , A61P11/00
CPC分类号： C12N15/113 , A61K31/712 , A61K31/713 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of STAT1 gene expression and/or activity, and/or modulate a STAT1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against STAT1 gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗响应STAT1基因表达和/或活性的调节和/或调节STAT1基因表达途径的性状，疾病和病症的化合物，组合物和方法。 具体地说，本发明涉及包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）等双链核酸分子， 和能够介导或介导针对STAT1基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。
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6.发明申请RNA Interference Mediated Inhibition of Apoptosis Signal-Regulating Kinase 1 (ASK1) Gene Expression Using Short Interfering Nucleic Acid (siNA) 审中-公开RNA干扰介导的细胞凋亡抑制信号调节激酶1（ASK1）基因表达使用短干扰核酸（siNA）公开(公告)号：US20120010272A1
公开(公告)日：2012-01-12
申请号：US13256089
申请日：2010-03-25
IPC分类号： A61K31/713 , A61P11/06 , A61P11/14 , C07H21/02 , A61P11/00
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2320/32 , C12N2320/51 , C12N2310/3521 , C12N2310/3533 , C12N2310/3531
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of ASK1 gene expression and/or activity, and/or modulate a ASK1 gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against ASK1 gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗对ASK1基因表达和/或活性的调节作用和/或调节ASK1基因表达途径的性状，疾病和病症的化合物，组合物和方法。 具体地说，本发明涉及包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）等双链核酸分子， 和能够介导或介导针对ASK1基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。
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7.发明申请RNA Interference Mediated Inhibition of the Nerve Growth Factor Beta Chain (NGFB) Gene Expression Using Short Interfering Nucleic Acid (siNA) 审中-公开RNA干扰介导的使用短干扰核酸（siNA）的神经生长因子β链（NGFB）基因表达的抑制公开(公告)号：US20120004281A1
公开(公告)日：2012-01-05
申请号：US13256105
申请日：2010-03-25
CPC分类号： C12N15/1136 , A61K31/712 , A61K31/713 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of NGFβ gene expression and/or activity, and/or modulate a NGFβ gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against NGFβ gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗对NGF和bgr的调节作用的性状，疾病和病症的化合物，组合物和方法; 基因表达和/或活性，和/或调节NGF和bgr; 基因表达途径。 具体地说，本发明涉及包括小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）等双链核酸分子， 和能够介导或介导针对NGF和bgr的RNA干扰（RNAi）的短发夹RNA（shRNA）分子; 基因表达。
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8.发明申请RNA Interference Mediated Inhibition of the High Affinity 1 gE Receptor Alpha Chain (FC Epsilon R1 Alpha) Gene Expression Using Short Interfering Nucleic Acid (siNA) 有权RNA干扰介导的使用短干扰核酸（siNA）的高亲和力1 gE受体α链（FC Epsilon R1 Alpha）基因表达的抑制作用公开(公告)号：US20120004280A1
公开(公告)日：2012-01-05
申请号：US13256095
申请日：2010-03-25
IPC分类号： A61K31/713 , C07H21/00 , A61P11/14 , A61P29/00 , A61P11/06 , A61P11/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/3515 , C12N2320/51 , C12N2310/3521 , C12N2310/3533 , C12N2310/3531
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of FCεR1α gene expression and/or or activity, and/or modulate a FCεR1α gene expression pathway. Specifically, the invention relates to doublestranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against FCεR1α gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗响应于FCα和R1α基因表达和/或/或活性的调节和/或调节FCα和Rαα的性状，疾病和病症的化合物，组合物和方法 基因表达途径。 具体地说，本发明涉及包括小核酸分子如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短链的双链核酸分子 能够介导或介导RNA干扰（RNAi）的发夹RNA（shRNA）分子与FCα和R1α基因表达的结合。
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公开(公告)号：US07049076B2
公开(公告)日：2006-05-23
申请号：US10888313
申请日：2004-07-09
申请人： Kevin J. Lee , Richard Axel , Walter Strapps , Gilad Barnea
发明人： Kevin J. Lee , Richard Axel , Walter Strapps , Gilad Barnea
CPC分类号： G01N33/6845 , C12N15/1055 , G01N33/9406 , G01N2333/726 , G01N2500/10
摘要： The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
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10.发明授权RNA interference mediated inhibition of prolyl hydroxylase domain 2 (PHD2) gene expression using short interfering nucleic acid (siNA) 有权RNA干扰介导使用短干扰核酸（siNA）抑制脯氨酰羟化酶结构域2（PHD2）基因表达公开(公告)号：US09233997B2
公开(公告)日：2016-01-12
申请号：US13818310
申请日：2011-08-24
申请人： Brandon Ason , Duncan Brown , Walter Strapps
发明人： Brandon Ason , Duncan Brown , Walter Strapps
IPC分类号： C12N15/11 , C07H21/00 , C07H21/02 , A61K31/713 , A61K45/06 , C12N15/113
CPC分类号： C12N15/1137 , A61K31/713 , A61K45/06 , C07H21/00 , C07H21/02 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/3525 , C12N2310/3533
摘要： The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of PHD2 gene expression and/or activity, and/or modulate a beta-catenin gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsR-NA), micro-RNA (miRNA), and short hair-pin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against PHD2 gene expression.
摘要翻译： 本发明涉及用于研究，诊断和治疗响应于PHD2基因表达和/或活性的调节和/或调节β-连环蛋白基因表达途径的性状，疾病和病症的化合物，组合物和方法 。 具体地说，本发明涉及包括小核酸分子如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsR-NA），微RNA（miRNA）的双链核酸分子 ）和能够介导或介导针对PHD2基因表达的RNA干扰（RNAi）的短发夹RNA（shRNA）分子。
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