A system and method are provided for determining a time for safely sampling a signal of a clock domain. In one embodiment, a frequency estimate of a first clock domain is calculated utilizing a frequency estimator. Additionally, a time during which a signal from the first clock domain is unchanging is determined such that the signal is capable of being safely sampled by a second clock domain, using the frequency estimate. In another embodiment, a frequency estimate of a first clock domain is calculated utilizing a frequency estimator. Further, a phase estimate of the first clock domain is calculated based on the frequency estimate, utilizing a phase estimator. Moreover, a time during which a signal from the first clock domain is unchanging is determined such that the signal is capable of being safely sampled by a second clock domain, using the phase estimate.