发明授权
- 专利标题： Combining radioimmunotherapy and antibody-drug conjugates for improved cancer therapy
-
申请号： US12957655申请日： 2010-12-01
-
公开(公告)号： US08435529B2公开(公告)日： 2013-05-07
- 发明人: Serengulam V. Govindan , David M. Goldenberg
- 申请人： Serengulam V. Govindan , David M. Goldenberg
- 申请人地址： US NJ Morris Plains
- 专利权人： Immunomedics, Inc.
- 当前专利权人： Immunomedics, Inc.
- 当前专利权人地址： US NJ Morris Plains
- 代理商 Richard A. Nakashima
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
Described herein are compositions and methods of use of radionuclide-antibody conjugates (for RAIT) and drug-antibody conjugates (ADC). The combination of RAIT and ADC was more efficacious than either RAIT alone, ADC alone, or the sum of effects of RAIT and ADC. The unexpected synergy resulted in decreased tumor growth rate and increased survival, with a high incidence of tumor-free survival in Capan-1 human pancreatic cancer xenografts in nude mice.
公开/授权文献
信息查询
