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1.发明申请Polymeric Carriers of Therapeutic Agents and Recognition Moieties for Antibody-Based Targeting of Disease Sites 有权治疗剂的聚合载体和用于基于抗体靶向疾病部位的识别部分公开(公告)号：US20120040431A1
公开(公告)日：2012-02-16
申请号：US13246389
申请日：2011-09-27
CPC分类号： A61K47/48315 , A61K31/4745 , A61K31/704 , A61K38/05 , A61K47/556 , A61K47/61 , A61K47/62 , A61K47/645 , A61K47/646 , A61K47/65 , A61K47/665 , A61K47/6951 , B82Y5/00 , C07K14/001 , C08B37/0021 , C08G83/003 , C08G83/004 , Y02A50/403
摘要： The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
摘要翻译： 本发明涉及用于将治疗剂递送至靶细胞，组织或生物体的方法和组合物。 在优选的实施方案中，治疗剂以治疗负荷聚合物的形式递送，其可以包含许多拷贝的一种或多种治疗剂。 在更优选的实施方案中，聚合物可以与含有一种或多种半抗原如HSG的肽部分缀合。 药剂 - 聚合物 - 肽复合物可以通过例如利用双特异性或多特异性抗体或片段的预靶向技术递送至靶细胞，所述双特异性或多特异性抗体或片段具有识别半抗原的至少一个结合臂和至少一个结合的结合臂 具体涉及疾病或病原体相关抗原，例如肿瘤相关抗原。 提供了合成和使用这种治疗负载型聚合物及其共轭物的方法。
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公开(公告)号：US08084583B2
公开(公告)日：2011-12-27
申请号：US12389503
申请日：2009-02-20
IPC分类号： C07K16/00
CPC分类号： A61K45/06 , A61K39/39558 , A61K51/1045 , A61K51/1051 , A61K2039/505 , C07K16/30 , C07K16/3015 , C07K2317/21 , C07K2317/24
摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.
摘要翻译： 本发明涉及单价和多价单特异性结合蛋白和多价多特异性结合蛋白。 这些结合蛋白的一个实施方案具有一个或多个结合位点，其中每个结合位点与靶抗原或靶抗原上的表位结合。 这些结合蛋白的另一个实施方案具有两个或更多个结合位点，其中每个结合位点对靶抗原上的不同表位具有亲和力，或对靶抗原或半抗原具有亲和力。 本发明还涉及可用于在宿主中表达这些功能性结合蛋白的重组载体。 更具体地，本发明涉及称为RS7的肿瘤相关抗原结合蛋白和其它EGP-1结合蛋白。 本发明还涉及人源化，人和嵌合RS7抗原结合蛋白，以及这种结合蛋白在诊断和治疗中的用途。
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3.发明授权Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites 有权用于疾病部位的基于抗体的靶向治疗剂和识别部分的聚合物载体公开(公告)号：US08067006B2
公开(公告)日：2011-11-29
申请号：US12766092
申请日：2010-04-23
IPC分类号： G01N33/544 , G01N33/548 , G01N33/547 , A61K39/395 , A61K38/16 , A61K39/44 , C07K17/06 , C07K16/22
CPC分类号： A61K47/48315 , A61K31/4745 , A61K31/704 , A61K38/05 , A61K47/556 , A61K47/61 , A61K47/62 , A61K47/645 , A61K47/646 , A61K47/65 , A61K47/665 , A61K47/6951 , B82Y5/00 , C07K14/001 , C08B37/0021 , C08G83/003 , C08G83/004 , Y02A50/403
摘要： The present invention concerns methods and compositions for delivery of therapeutic agents to target cells, tissues or organisms. In preferred embodiments, the therapeutic agents are delivered in the form of therapeutic-loaded polymers that may comprise many copies of one or more therapeutic agents. In more preferred embodiments, the polymer may be conjugated to a peptide moiety that contains one or more haptens, such as HSG. The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. Methods for synthesizing and using such therapeutic-loaded polymers and their conjugates are provided.
摘要翻译： 本发明涉及用于将治疗剂递送至靶细胞，组织或生物体的方法和组合物。 在优选的实施方案中，治疗剂以治疗负荷聚合物的形式递送，其可以包含许多拷贝的一种或多种治疗剂。 在更优选的实施方案中，聚合物可以与含有一种或多种半抗原如HSG的肽部分缀合。 药剂 - 聚合物 - 肽复合物可以通过例如利用双特异性或多特异性抗体或片段的预靶向技术递送至靶细胞，所述双特异性或多特异性抗体或片段具有识别半抗原的至少一个结合臂和至少一个结合的结合臂 具体涉及疾病或病原体相关抗原，例如肿瘤相关抗原。 提供了合成和使用这种治疗负载型聚合物及其共轭物的方法。
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公开(公告)号：US08741300B2
公开(公告)日：2014-06-03
申请号：US13291238
申请日：2011-11-08
CPC分类号： A61K47/6803 , A61K31/4745 , A61K45/06 , A61K47/6841 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K47/6855 , A61K47/6857 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/10 , C07D491/22 , C07K16/1063 , C07K16/18 , C07K16/2803 , C07K16/2833 , C07K16/2863 , C07K16/2887 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K16/3076 , C07K16/3092 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/52 , C07K2317/53 , C07K2317/94 , Y02A50/394 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/473 , Y02A50/478
摘要： The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
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公开(公告)号：US08617558B2
公开(公告)日：2013-12-31
申请号：US13586541
申请日：2012-08-15
IPC分类号： A61K39/00
CPC分类号： A61K45/06 , A61K47/60 , A61K47/6803 , A61K47/6839 , A61K47/6841 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6863 , A61K47/6865 , A61K47/6867 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/1063 , C07K16/2803 , C07K16/2833 , C07K16/2863 , C07K16/30 , C07K2317/73 , Y02A50/403
摘要： The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.
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公开(公告)号：US08435529B2
公开(公告)日：2013-05-07
申请号：US12957655
申请日：2010-12-01
IPC分类号： A61K39/395
CPC分类号： A61K51/1057 , A61K31/4745 , A61K31/7068 , A61K39/39558 , A61K41/0038 , A61K45/06 , A61K47/643 , A61K47/6803 , A61K47/6857 , A61K47/6859 , A61K51/08 , A61K51/109 , A61K2039/505 , A61K2039/507 , B82Y5/00 , C07K16/30 , C07K16/303 , C07K16/3092 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/77 , A61K2300/00
摘要： Described herein are compositions and methods of use of radionuclide-antibody conjugates (for RAIT) and drug-antibody conjugates (ADC). The combination of RAIT and ADC was more efficacious than either RAIT alone, ADC alone, or the sum of effects of RAIT and ADC. The unexpected synergy resulted in decreased tumor growth rate and increased survival, with a high incidence of tumor-free survival in Capan-1 human pancreatic cancer xenografts in nude mice.
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公开(公告)号：US08080250B1
公开(公告)日：2011-12-20
申请号：US13164275
申请日：2011-06-20
IPC分类号： A61K39/395
CPC分类号： A61K47/6803 , A61K31/4745 , A61K45/06 , A61K47/6841 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K47/6855 , A61K47/6857 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/10 , C07D491/22 , C07K16/1063 , C07K16/18 , C07K16/2803 , C07K16/2833 , C07K16/2863 , C07K16/2887 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K16/3076 , C07K16/3092 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/52 , C07K2317/53 , C07K2317/94 , Y02A50/394 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/473 , Y02A50/478
摘要： The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
摘要翻译： 本发明涉及具有改善靶向各种含有靶向部分（例如抗体或抗体片段）的病变细胞，接头和治疗部分的能力的治疗性缀合物，还涉及制备和使用缀合物的方法。
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公开(公告)号：US20110293513A1
公开(公告)日：2011-12-01
申请号：US13164275
申请日：2011-06-20
IPC分类号： A61K39/395 , A61P37/06 , A61K51/10 , A61P31/12 , A61P17/00 , A61P29/00 , A61P35/00 , A61P31/04
CPC分类号： A61K47/6803 , A61K31/4745 , A61K45/06 , A61K47/6841 , A61K47/6849 , A61K47/6851 , A61K47/6853 , A61K47/6855 , A61K47/6857 , A61K47/6861 , A61K47/6889 , A61K2039/505 , A61N5/10 , C07D491/22 , C07K16/1063 , C07K16/18 , C07K16/2803 , C07K16/2833 , C07K16/2863 , C07K16/2887 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K16/3076 , C07K16/3092 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/52 , C07K2317/53 , C07K2317/94 , Y02A50/394 , Y02A50/401 , Y02A50/403 , Y02A50/412 , Y02A50/473 , Y02A50/478
摘要： The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates.
摘要翻译： 本发明涉及具有改善靶向各种含有靶向部分（例如抗体或抗体片段）的病变细胞，接头和治疗部分的能力的治疗性缀合物，还涉及制备和使用缀合物的方法。
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公开(公告)号：US07591994B2
公开(公告)日：2009-09-22
申请号：US12026811
申请日：2008-02-06
IPC分类号： A61K39/395
CPC分类号： A61K45/06 , A61K47/60 , A61K47/6803 , A61K47/6839 , A61K47/6841 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6863 , A61K47/6865 , A61K47/6867 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/1063 , C07K16/2803 , C07K16/2833 , C07K16/2863 , C07K16/30 , C07K2317/73 , Y02A50/403
摘要： The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.
摘要翻译： 本发明涉及具有改进的靶向各种患有靶向部分（例如抗体或抗体片段），接头和喜树碱作为治疗部分的病变细胞的能力的治疗性缀合物，还涉及制备和使用所述缀合物的方法 。
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公开(公告)号：US20080166363A1
公开(公告)日：2008-07-10
申请号：US12026811
申请日：2008-02-06
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , A61P31/00 , A61P37/00
CPC分类号： A61K45/06 , A61K47/60 , A61K47/6803 , A61K47/6839 , A61K47/6841 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6859 , A61K47/6861 , A61K47/6863 , A61K47/6865 , A61K47/6867 , A61K47/6869 , A61K47/6889 , A61K2039/505 , C07K16/1063 , C07K16/2803 , C07K16/2833 , C07K16/2863 , C07K16/30 , C07K2317/73 , Y02A50/403
摘要： The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a camptothecin as a therapeutic moiety, and further relates to processes for making and using the said conjugates.
摘要翻译： 本发明涉及具有改进的靶向各种患有靶向部分（例如抗体或抗体片段），接头和喜树碱作为治疗部分的病变细胞的能力的治疗性缀合物，还涉及制备和使用所述缀合物的方法 。
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