发明授权
US08450479B2 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5-tetrazine-8-carboxylic acid amides and their use
有权
3-取代-4-氧代-3,4-二氢 - 咪唑并[5,1-d] [1,2,3,5-四嗪-8-羧酸酰胺及其用途
![3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5-tetrazine-8-carboxylic acid amides and their use](/docs/US/2013-05-28/US08450479B2/abs.jpg.600x600.jpg)
- 专利标题： 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5-tetrazine-8-carboxylic acid amides and their use
- 专利标题（中）： 3-取代-4-氧代-3,4-二氢 - 咪唑并[5,1-d] [1,2,3,5-四嗪-8-羧酸酰胺及其用途
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申请号： US12808604申请日： 2008-12-16
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公开(公告)号： US08450479B2公开(公告)日： 2013-05-28
- 发明人: Malcolm Francis Graham Stevens , David Cousin , Sharon Jennings , Andrew James McCarroll , John Gareth Williams , Marc Geoffery Hummersone , Jihong Zhang
- 申请人： Malcolm Francis Graham Stevens , David Cousin , Sharon Jennings , Andrew James McCarroll , John Gareth Williams , Marc Geoffery Hummersone , Jihong Zhang
- 申请人地址： GB Nottingham
- 专利权人： Pharminox Limited
- 当前专利权人： Pharminox Limited
- 当前专利权人地址： GB Nottingham
- 代理机构： Swanson & Bratschun, L.L.C.
- 国际申请： PCT/GB2008/004140 WO 20081216
- 国际公布： WO2009/077741 WO 20090625
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D519/00 ; C07F7/10 ; C07F9/141 ; A61K31/395 ; A61K31/4188 ; A61P35/00
![3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5-tetrazine-8-carboxylic acid amides and their use](/abs-image/US/2013/05/28/US08450479B2/abs.jpg.150x150.jpg)
摘要：
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds.
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