发明授权
US08457902B2 Method for selecting SIRNAs from a plurality of SIRNAs for gene silencing
有权
用于从多个SIRNA中选择用于基因沉默的SIRNA的方法
- 专利标题： Method for selecting SIRNAs from a plurality of SIRNAs for gene silencing
- 专利标题（中）： 用于从多个SIRNA中选择用于基因沉默的SIRNA的方法
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申请号： US13100836申请日： 2011-05-04
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公开(公告)号： US08457902B2公开(公告)日： 2013-06-04
- 发明人: Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
- 申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理机构： Christensen O'Connor Johnson Kindness PLLC
- 主分类号： G06F7/00
- IPC分类号： G06F7/00
摘要：
The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
公开/授权文献
- US20110250591A1 METHOD OF DESIGNING siRNAS FOR GENE SILENCING 公开/授权日：2011-10-13
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