Invention Grant
US08466121B2 Method of selectively inhibiting the activity of ACAT1 in the treatment of Alzheimer's disease
有权
选择性抑制ACAT1在治疗阿尔茨海默病中的活性的方法
- Patent Title: Method of selectively inhibiting the activity of ACAT1 in the treatment of Alzheimer's disease
- Patent Title (中): 选择性抑制ACAT1在治疗阿尔茨海默病中的活性的方法
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Application No.: US13072915Application Date: 2011-03-28
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Publication No.: US08466121B2Publication Date: 2013-06-18
- Inventor: Ta-Yuan Chang , Catherine C. Y. Chang
- Applicant: Ta-Yuan Chang , Catherine C. Y. Chang
- Applicant Address: US NH Hanover
- Assignee: Trustees of Dartmouth College
- Current Assignee: Trustees of Dartmouth College
- Current Assignee Address: US NH Hanover
- Agency: Licata & Tyrrell P.C.
- Main IPC: A01N43/04
- IPC: A01N43/04 ; C12Q1/68 ; C12N15/63 ; C07H21/02 ; C07H21/04
Abstract:
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.
Public/Granted literature
- US20110237656A1 Method of Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease Public/Granted day:2011-09-29
Information query
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