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公开(公告)号：US4911720A
公开(公告)日：1990-03-27
申请号：US474179
申请日：1983-03-10
Applicant: John P. Collier
Inventor： John P. Collier
CPC classification number: A61F2/30767 , A61F2/3603 , A61F2/3859 , A61F2/389 , A61F2002/30354 , A61F2220/0033
Abstract: An articular surface prosthesis composed of a porous material that is substantially noncorrodible and nonbiodegradible by body fluids. The prosthesis serves as a replacement of, for example, a femoral cap. The prosthesis fits over the femur which is shaped, typically, to a right circular cylinder outline, to receive the replacement which has a similarly shaped cavity. The prosthesis fits snugly over the femur and presents at the bone prosthesis interface coarse pores (e.g., 100 to 500 micrometers) to permit bone ingrowth; the pores are graded toward smaller or fine sizes (e.g.,
Abstract translation: 由多孔材料组成的关节表面假体，其基本上是非可矫治的，并且被体液不可生物降解。 假体用作例如股骨帽的替代物。 该假体适合于通常成形为右圆形圆柱轮廓的股骨，以接收具有类似形状的腔的置换。 假体紧贴在股骨上方并呈现在骨假体界面处的粗糙孔（例如，100至500微米）以允许骨向内生长; 孔被分级为较小或精细的尺寸（例如，<50微米），以防止骨向内生长并允许软骨在假体的关节侧向内生长。
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公开(公告)号：US20250002852A1
公开(公告)日：2025-01-02
申请号：US18762762
申请日：2024-07-03
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Charles L. Sentman
IPC: C12N5/0783 , A61K35/12 , A61K39/00
Abstract: The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TOR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TOR-deficient T cells are designed to express a functional non-TOR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TOR-deficient T cells, populations thereof, or compositions comprising the same.
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公开(公告)号：US20250002584A1
公开(公告)日：2025-01-02
申请号：US18767080
申请日：2024-07-09
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Charles L. SENTMAN , Tong ZHANG
IPC: C07K16/28 , A61K39/395 , C07K14/705 , C07K14/725
Abstract: Antibodies, chimeric antigen receptors, and bispecific T-cell engagers having specificity for B7-H6 and methods for using the same in the diagnosis and treatment of disorders associated with B7-H6 expression are provided.
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公开(公告)号：US20250000964A1
公开(公告)日：2025-01-02
申请号：US18703610
申请日：2022-10-24
Applicant: TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Steven Fiering , Hugo Arias-Pulido , Laura Pena , Nicole F. Steinmetz , Gregory W. Ho
Abstract: A neoadjuvant for use in treating cancer includes an in situ vaccine and optionally an immune check point therapeutic. The in situ vaccine includes at least one of cowpea mosaic virus or cowpea mosaic virus-like particles.
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公开(公告)号：US12133892B2
公开(公告)日：2024-11-05
申请号：US18175433
申请日：2023-02-27
Inventor： Samuel F. Bakhoum , Bassem I. Zaki , Duane A. Compton
Abstract: Disclosed is a method for increasing susceptibility of cancer cells to ionizing radiation by delivering to the cells a radiosensitizing agent that has one of the following properties: (a) it perturbs the process of chromosome segregation thereby increasing chromosome missegregation; or (b) it is an inhibitor of an agent that promotes faithful chromosome segregation induces numeric chromosome instability in said cells and this instability is induced substantially simultaneously with or closely prior to or closely after irradiating the cells. Examples of such radiosensitizing agent include inhibitors of one or more of the following: Kif2b, MCAK, MPS1, Eg5/Kinesin-5 5, Polo-like kinase 4, MCAK, Bub1 and Hec1. Such agents specifically target proteins involved in maintaining or promoting faithful chromosome segregation.
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Patent Agency Ranking
6.发明公开公开(公告)号：US20240302319A1
公开(公告)日：2024-09-12
申请号：US18601999
申请日：2024-03-11
Applicant: TRUSTEES OF DARTMOUTH COLLEGE
IPC: G01N27/327 , G01N27/30
CPC classification number: G01N27/3277 , G01N27/307 , G01N27/308
Abstract: A probe includes a fast-scanning cyclic voltammetry electrode, a conductive wall disposed around the fast-scanning cyclic voltammetry electrode, and a wire in electronic communication with the fast-scanning cyclic voltammetry electrode. The conductive wall is grounded. Fast scanning cyclic voltammetry electrode currents are enclosed within the conductive wall. Resulting fast scanning cyclic voltammetry can have sub-μV level artifacts.
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公开(公告)号：US20240299091A1
公开(公告)日：2024-09-12
申请号：US18562514
申请日：2022-01-28
Applicant: The Trustees of Dartmouth College , Mary Hitchcock Memorial Hospital, For Itself and On Behalf of Dartmouth-Hitchcock Clinic
Inventor： Kevin F. KWAKU , Alexander HATTOUM , B. Stuart TREMBLY
CPC classification number: A61B18/16 , A61B18/1206 , A61B18/1492 , A61B2018/00577 , A61B2018/00613 , A61B2018/1253 , A61B2018/1266 , A61B2018/165 , A61B2018/167
Abstract: A tissue ablation system and method are provided. The system includes a catheter including a distal electrode tip having at least one tip electrode, at least one return electrode positionable independently of the tip electrode, and a voltage generator circuit electrically connected to the tip electrode and to the return electrode. The tip electrode and the return electrode include a dielectric or other non-conductive surface layer. The voltage generator circuit applies a voltage differential across the tip electrode and the return electrode such that the tip electrode and the return electrode are given opposite polarity. Tissue located between the tip electrode and the return electrode acts as a capacitive dielectric medium in which an electric field is present and is not dependent on current flow between the tip electrode and the return electrode, and the electric field induces electroporation of tissue cells in a vicinity of the distal electrode tip.
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公开(公告)号：US20240268698A1
公开(公告)日：2024-08-15
申请号：US18568940
申请日：2022-06-10
Applicant: The Trustees of Dartmouth College
Inventor： ALLAIRE DOUSSAN , RYAN HALTER , ETHAN MURPHY
IPC: A61B5/0536 , A61B5/00
CPC classification number: A61B5/0536 , A61B5/6843 , A61B5/7264
Abstract: A bioimpedance device for surgical cavities has pick-up electrodes surrounded by driving electrodes, each driving electrode having greater area than the pick-up electrodes, the electrode array coupled through an adjacent connector to an electronics module. The electronics module fits through laparoscopic ports. The electronics module includes a voltage controlled current source, multiplexing for driving electrodes, a force sensor, and voltage buffers, and couples to a data acquisition system coupled to a processor. The processor uses the apparatus to perform bioimpedance mapping of tissue. A method of mapping bioimpedance includes contacting tissue with the electrode array, sequentially driving at least one of the driving electrodes with an alternating current at frequencies between 100 and 1000000 hertz while reading the sense electrodes through analog to digital converters into the processor; using readings of the sense electrodes to generate a bioimpedance map of the tissue; the electrode array fitting through laparoscopic ports.
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公开(公告)号：US12061328B2
公开(公告)日：2024-08-13
申请号：US18144767
申请日：2023-05-08
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Pablo A. Valdes , David W. Roberts , Keith D. Paulsen , Frederic Leblond
Abstract: An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output port at which at least a portion of the received light is provided as an output from the surgical microscope. A tunable filter receives the portion of the received light provided as the output from the surgical microscope, the tunable filter being tunable to pass a filtered portion of the received light, the filtered portion of the received light having a plurality of wavelengths selected by the tunable filter and provided as output from the tunable filter. A high-resolution, broad-bandwidth electronic camera receives the light of a plurality of wavelengths selected by the tunable filter, the electronic camera converting the light of a plurality of wavelengths selected by the tunable filter to a plurality of electrical signals. A processor processes the plurality of electrical signals to form an image of the target.
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公开(公告)号：US12060394B2
公开(公告)日：2024-08-13
申请号：US16096562
申请日：2017-04-28
Applicant: THE TRUSTEES OF DARTMOUTH COLLEGE
Inventor： Charles L. Sentman , Albert Gacerez
IPC: C07K14/47 , A61K35/17 , A61P35/00 , C07K14/705 , C07K14/725 , C07K16/28 , C12N15/86
CPC classification number: C07K14/4702 , A61K35/17 , A61P35/00 , C07K14/7051 , C07K14/70521 , C07K16/2827 , C12N15/86 , C07K2317/622 , C07K2319/03 , C07K2319/33 , C12N2740/10043
Abstract: Nucleic acid constructs, vectors, and recombinant cells harboring the nucleic acid constructs or vectors are disclosed. The nucleic acid constructs include genes encoding a chimeric antigen receptor (CAR) and/or one or more transcription factors, optionally mutated. The transcription factors include those that mediate proinflammatory cytokine expression, e.g., T-bet, STAT1, or STAT4. Methods are disclosed of co-expression of the CAR and the transcription factor in a human or non-human immune cell, preferably human T cells. Also disclosed are methods for using these cells for immunotherapy, e.g., in treating cancer, infection, autoimmunity, allergy or inflammation diseases by the administration of a prophylactically or therapeutically effective amount of one or more of the nucleic acid constructs, vectors, and/or immune cells, e.g., human CAR-T cells, described herein.
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