发明授权
US08466124B2 RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
有权
RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱
- 专利标题： RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles
- 专利标题（中）： RNA序列基序在定义的核苷酸间键的背景下诱导特异性免疫调节谱
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申请号： US13494216申请日： 2012-06-12
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公开(公告)号： US08466124B2公开(公告)日： 2013-06-18
- 发明人: Marion Jurk , Jorg Vollmer
- 申请人： Marion Jurk , Jorg Vollmer
- 申请人地址： DE Dusseldorf
- 专利权人： Coley Pharmaceutical GmbH
- 当前专利权人： Coley Pharmaceutical GmbH
- 当前专利权人地址： DE Dusseldorf
- 代理商 Paul M. Misiak; Vyacheslav V. Vasilyev
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12Q1/68 ; C07H21/02 ; C12N5/02 ; C12N5/00 ; C07H21/04
摘要：
Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immunostimulatory RNA motifs and the polymers incorporating such motifs are potent and selective inducers of TLR7 and the TLR7-associated cytokine IFN-α.
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