发明授权
- 专利标题: (aza)indole derivative and use thereof for medical purposes
- 专利标题(中): (氮杂)吲哚衍生物及其用于医疗目的的用途
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申请号: US13116389申请日: 2011-05-26
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公开(公告)号: US08466152B2公开(公告)日: 2013-06-18
- 发明人: Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
- 申请人: Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
- 申请人地址: JP Matsumoto-shi
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Matsumoto-shi
- 代理机构: Westerman, Hattori, Daniels & Adrian, LLP
- 优先权: JP2007-104096 20070411
- 主分类号: A61K31/404
- IPC分类号: A61K31/404 ; A61K31/437 ; A61K31/5025 ; A61K31/519 ; C07D209/10 ; C07D209/30 ; C07D209/42 ; C07D471/04 ; C07D487/14
摘要:
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, nitro, alkyl, alkoxy and the like; X1, X2 and X3 independently represent CR2 or N; R1 and R2 independently represent halogen, cyano, haloalkyl, A-D-E-G, —N(-D-E-G)2 and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO2 and the like.
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