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    LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME
    4.
    发明公开
    LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME 审中-公开

    公开(公告)号：US20240124400A1

    公开(公告)日：2024-04-18

    申请号：US17768152

    申请日：2020-10-12

    申请人： DUKE UNIVERSITY

    发明人： Pei Zhou ,  Jiyong Hong

    IPC分类号： C07D209/30 ,  C07C311/20 ,  C07H11/04

    CPC分类号： C07D209/30 ,  C07C311/20 ,  C07H11/04

    摘要： LpxH targeting compounds, compositions thereof, as well as methods for for making and using the same are disclosed herein. The LpxH target compounds typically have a structure pursuant to Formula (I) and/or a salt thereof, wherein Rb is selected from a single bond, C4 to C10 unsubstituted aryl, C4 to C10 substituted aryl, unsubstituted or substituted four to ten member heterocycle ring, C1 to C10 unsubstituted alkyl, and C1 to C10 substituted alkyl; Rc comprises hydrogen, halogen, —OH, —CO2CH3, —COOH, —CN2CF3, —CF3, —C2OH, —CONHOH, —CCOH, C4 to C10 unsubstituted aryl, C4 to C10 substituted aryl, unsubstituted or substituted four to ten member heterocycle ring, C1 to C10 unsubstituted alkyl, or C1 to C10 substituted alkyl; and Rd and Re are independently hydrogen, —OH, —COH, —COH, —COC, —COOH, Rf, or are taken together as an unsubstituted or substituted four to eight member nitrogen containing heterocycle ring.

    MODULATORS OF E3 LIGASES
    6.
    发明公开
    MODULATORS OF E3 LIGASES 审中-公开

    公开(公告)号：US20230227406A1

    公开(公告)日：2023-07-20

    申请号：US18009972

    申请日：2021-06-14

    申请人： Rekindle Therapeutics Inc.

    发明人： Arthur F. Kluge ,  Soumya Ray ,  Suresh K. Jain ,  Detlev Biniszkiewicz ,  Ekambar R. Kandimalla ,  Joshua Grady

    IPC分类号： C07D209/12 ,  C07D209/30 ,  C07D417/12 ,  A61P35/00

    CPC分类号： C07D209/12 ,  C07D209/30 ,  C07D417/12 ,  A61P35/00

    摘要： Provided herein are methods, oligonucleotides, and compositions for modulating levels of at least one target protein in a cell, e.g., by reducing levels of the mRNA of the target protein or inhibiting translation of the mRNA. In some embodiments, the target protein can be the ubiquitin ligase polypeptide, including, but not limited to WWP1, WWP2, and NEDD4. Also provided herein are methods, oligonucleotides, and compositions for treating, ameliorating, delaying or reducing a symptom of a cancer. The present disclosure also relates to compounds, methods and compositions for modulating at least one target protein selected from ubiquitin protein ligase. Also provided herein are compounds, methods, and compositions for treating, ameliorating, delaying or reducing a symptom of a cancer or a viral infection. In particular, the present disclosure is directed to specific small-molecule modulators of HECT domain E3 ligases that are useful in the therapy and diagnosis of cancer and viral infection.