发明授权
US08466153B2 Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists
有权
哌啶基氨基哒嗪及其作为快速解离多巴胺2受体拮抗剂的用途
- 专利标题： Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists
- 专利标题（中）： 哌啶基氨基哒嗪及其作为快速解离多巴胺2受体拮抗剂的用途
-
申请号： US12516645申请日： 2007-12-05
-
公开(公告)号： US08466153B2公开(公告)日： 2013-06-18
- 发明人: Gregor James MacDonald , José Ignacio Andrés-Gil , Frans Alfons Maria Van Den Keybus , José Manuel Bartolomé-Nebreda , Michiel Luc Maria Van Gool
- 申请人： Gregor James MacDonald , José Ignacio Andrés-Gil , Frans Alfons Maria Van Den Keybus , José Manuel Bartolomé-Nebreda , Michiel Luc Maria Van Gool
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人： Janssen Pharmaceutica N.V.
- 当前专利权人地址： BE Beerse
- 代理商 Peter Herridge
- 优先权： EP06125685 20061208
- 国际申请： PCT/EP2007/063338 WO 20071205
- 国际公布： WO2008/068277 WO 20080612
- 主分类号： A61K31/501
- IPC分类号： A61K31/501 ; C07D237/20 ; A61P25/28
摘要：
The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles of the general formula (I); or a pharmaceutically acceptable salt thereof, or a stereoisomeric form, that are fast dissociating dopamine 2 receptor antagonists, as well as processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
公开/授权文献
- US20100076187A1 FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS 公开/授权日：2010-03-25