Invention Grant
US08466153B2 Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists
有权
哌啶基氨基哒嗪及其作为快速解离多巴胺2受体拮抗剂的用途
- Patent Title: Piperidinylamino-pyridazines and their use as fast dissociating dopamine 2 receptor antagonists
- Patent Title (中): 哌啶基氨基哒嗪及其作为快速解离多巴胺2受体拮抗剂的用途
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Application No.: US12516645Application Date: 2007-12-05
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Publication No.: US08466153B2Publication Date: 2013-06-18
- Inventor: Gregor James MacDonald , José Ignacio Andrés-Gil , Frans Alfons Maria Van Den Keybus , José Manuel Bartolomé-Nebreda , Michiel Luc Maria Van Gool
- Applicant: Gregor James MacDonald , José Ignacio Andrés-Gil , Frans Alfons Maria Van Den Keybus , José Manuel Bartolomé-Nebreda , Michiel Luc Maria Van Gool
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica N.V.
- Current Assignee: Janssen Pharmaceutica N.V.
- Current Assignee Address: BE Beerse
- Agent Peter Herridge
- Priority: EP06125685 20061208
- International Application: PCT/EP2007/063338 WO 20071205
- International Announcement: WO2008/068277 WO 20080612
- Main IPC: A61K31/501
- IPC: A61K31/501 ; C07D237/20 ; A61P25/28
Abstract:
The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles of the general formula (I); or a pharmaceutically acceptable salt thereof, or a stereoisomeric form, that are fast dissociating dopamine 2 receptor antagonists, as well as processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
Public/Granted literature
- US20100076187A1 FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS Public/Granted day:2010-03-25
Information query
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