发明授权
US08470831B2 Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition
有权
丙烯酰胺衍生物可用作线粒体通透性转换的抑制剂
- 专利标题： Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition
- 专利标题（中）： 丙烯酰胺衍生物可用作线粒体通透性转换的抑制剂
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申请号： US13123852申请日： 2009-09-23
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公开(公告)号： US08470831B2公开(公告)日： 2013-06-25
- 发明人: Daniele Fancelli , Mario Varasi , Simon Plyte , Marco Ballarini , Anna Cappa , Giacomo Carenzi , Saverio Minucci , Gilles Pain , Manuela Villa
- 申请人： Daniele Fancelli , Mario Varasi , Simon Plyte , Marco Ballarini , Anna Cappa , Giacomo Carenzi , Saverio Minucci , Gilles Pain , Manuela Villa
- 申请人地址： IT Milan
- 专利权人： Cogenia SRL
- 当前专利权人： Cogenia SRL
- 当前专利权人地址： IT Milan
- 代理机构： Cooper & Dunham LLP
- 代理商 Gary J. Gershik
- 优先权： EP08018742 20081027
- 国际申请： PCT/IB2009/006939 WO 20090923
- 国际公布： WO2010/049768 WO 20100506
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; A61K31/445 ; A61K31/4178 ; A61K31/416 ; A61K31/22 ; A61K31/19 ; A61K31/18 ; A61K31/167 ; C07D295/12 ; C07D241/04 ; C07D211/32 ; C07D403/06 ; C07D231/56 ; C07D295/096 ; C07C69/017 ; C07C65/19 ; C07C311/13 ; C07C233/88
摘要：
Acrylamido derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of the mitochondrial permeability transition pore (MPTP), such as the diseases characterized by ischemia/reperfusion, oxidative or degenerative tissue damage, are herein described. These compounds belong to the structural formula (I) wherein R, R′, R″, W and a are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to pharmaceutical compositions comprising them.