发明授权
- 专利标题： Methods relating to aromatase inhibitor pharmacogenetics
- 专利标题（中）： 涉及芳香酶抑制剂药物遗传学的方法
-
申请号： US12852957申请日： 2010-08-09
-
公开(公告)号： US08476023B2公开(公告)日： 2013-07-02
- 发明人: Philip Lazarus , Dongxiao Sun
- 申请人： Philip Lazarus , Dongxiao Sun
- 申请人地址： US PA University Park
- 专利权人： The Penn State Research Foundation
- 当前专利权人： The Penn State Research Foundation
- 当前专利权人地址： US PA University Park
- 代理机构： Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N15/54 ; C12N15/52
摘要：
Methods for aiding in determining therapeutic efficacy of an aromatase inhibitor in a subject are provided according to embodiments of the present invention which include detecting expression and/or function of at least one UDP-glucuronosyltransferase having activity to modify at least one aromatase inhibitor and/or metabolite of the aromatase inhibitor by glucuronidation, wherein detection of expression and/or function of the UDP-glucuronosyltransferase is correlated with therapeutic efficacy of the aromatase inhibitor in the subject. Detection of UDP-glucuronosyltransferase expression and/or function includes detection of a UDP-glucuronosyltransferase gene deletion polymorphism in the subject.
公开/授权文献
- US20110033856A1 METHODS RELATING TO AROMATASE INHIBITOR PHARMACOGENETICS 公开/授权日：2011-02-10
信息查询
