公开(公告)号：US10975403B2

公开(公告)日：2021-04-13

申请号：US16032800

申请日：2018-07-11

申请人： Conagen Inc.

发明人： Rui Zhou ,  Xiaodan Yu ,  Steven Chen

IPC分类号： C12N15/70 ,  C12N15/54 ,  C12N9/06 ,  C12N9/24 ,  C12P17/06 ,  A61K8/99 ,  A61K8/49 ,  A23L27/00 ,  A23L27/30 ,  A23L33/10 ,  A61Q19/00 ,  C07D311/32 ,  C12N15/81 ,  A61Q5/00

摘要： The present invention relates to the production of eriodictyol via bioconversion.

公开(公告)号：US10233431B2

公开(公告)日：2019-03-19

申请号：US14633076

申请日：2015-02-26

申请人： The Regents of the University of California

发明人： Satoshi Yuzawa ,  Leonard Katz ,  Jay D. Keasling

IPC分类号： C12P7/26 ,  C12P7/42 ,  C12N9/10 ,  C12N9/02 ,  C12N9/16 ,  C12N15/54 ,  C12N15/53 ,  C12N15/55 ,  C12N15/31 ,  C07K14/39 ,  C07K19/00 ,  C12N9/04 ,  C07K14/36

摘要： The present invention provides for a polyketide synthase (PKS) capable of synthesizing a 3-hydroxycarboxylic acid or ketone. The present invention also provides for a host cell comprising the PKS and when cultured produces the 3-hydroxycarboxylic acid or ketone.

公开(公告)号：US09944908B2

公开(公告)日：2018-04-17

申请号：US14410941

申请日：2012-11-29

申请人： HELSINGIN YLIOPISTO

发明人： Anne Vatèn ,  Jan Dettmer ,  Shunsuke Miyashima ,  Shri Ram Yadav ,  Ana Campilho ,  Vincent Bulone ,  Raffael Lichtenberger ,  Satu Lehesranta ,  Ari Pekka Mähönen ,  Annelie Carlsbecker ,  Yrjö Helariutta ,  Kaori Furuta

IPC分类号： A01H5/10 ,  C12N15/82 ,  C12N15/54 ,  C12N9/10 ,  A61K9/00

CPC分类号： C12N9/1051 ,  A61K9/0075 ,  C12N15/8246 ,  C12N15/8261 ,  C12N15/8271 ,  C12Y204/01034

摘要： The present invention relates to a polypeptide, or a fragment thereof, capable of enhancing callose biosynthesis and/or accumulation, wherein at least one of the conserved amino acid residues selected from the group consisting of residue corresponding to R84 of SEQ ID NO: 1, residue corresponding to R1926 or SEQ ID NO: 1 and residue corresponding to P189 of SEQ ID NO: 1, of the polypeptide or a fragment thereof, is modified by a mutation selected from the group consisting of substitution and deletion.

公开(公告)号：US09902967B2

公开(公告)日：2018-02-27

申请号：US14563083

申请日：2014-12-08

申请人： E I DU PONT DE NEMOURS AND COMPANY

发明人： Howard Glenn Damude ,  William D Hitz ,  Knut Meyer ,  Narendra S Yadav

IPC分类号： C12N15/54 ,  A01H5/10 ,  C12N15/82 ,  C12N9/10

CPC分类号： C12N15/8247 ,  C12N9/1029 ,  C12Y203/01158

摘要： Transgenic soybean seed having increased total fatty acid content of at least 10% and altered fatty acid profiles when compared to the total fatty acid content of non-transgenic, null segregant soybean seed are described. DGAT genes from Yarrowia Lipolytica are used to achieve the increase in seed storage lipids.

公开(公告)号：US09790531B2

公开(公告)日：2017-10-17

申请号：US15356132

申请日：2016-11-18

申请人： ModernaTX, Inc.

发明人： Yuxun Wang ,  Divakar Ramakrishnan ,  Antonin De Fougerolles ,  Susan Whoriskey

IPC分类号： C12P19/34 ,  C12N9/12 ,  C12N15/52 ,  C12N15/54 ,  C12N15/63 ,  C12N15/70

CPC分类号： C12P19/34 ,  C12N9/1241 ,  C12N9/1247 ,  C12N9/1252 ,  C12Y207/07006 ,  C12Y207/07007 ,  C12Y207/0705

摘要： The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US08748155B2

公开(公告)日：2014-06-10

申请号：US13720574

申请日：2012-12-19

申请人： An Educational Foundation Kinki University ,  Dainihon Jochugiku Co., Ltd.

发明人： Kazuhiko Matsuda ,  Yukio Kikuta

IPC分类号： C12N1/21 ,  C12N9/10 ,  C12N15/11 ,  C12N15/54 ,  C12N15/62 ,  C12N15/63

CPC分类号： C12N9/1025 ,  C07K14/415 ,  C12N9/1029 ,  C12N9/14 ,  C12N15/8243

摘要： Amino acid sequences of an enzyme involved in pyrethrin biosynthesis and a base sequence of the gene thereof; constructing vectors bearing the gene and transformants; and extractable from plant bodies producing pyrethrin by applying such creative techniques to plant bodies with faster growth aiming to provide a method to efficiently produce pyrethrin. A gene encoding a protein consisting of the amino acid sequence of SEQ ID NO: 1. A protein consisting of the amino acid sequence of SEQ ID NO: 2.

摘要翻译： 涉及除虫菊酯生物合成的酶的氨基酸序列及其基因的碱基序列; 构建带有基因和转化体的载体; 并且通过将这种创造性技术应用于具有更快增长的植物体，从而产生除虫菊酯的植物体可提取，目的在于提供一种有效生产除虫菊酯的方法。 编码由SEQ ID NO：1的氨基酸序列组成的蛋白质的基因。由SEQ ID NO：2的氨基酸序列组成的蛋白质。

公开(公告)号：US08722380B2

公开(公告)日：2014-05-13

申请号：US13162688

申请日：2011-06-17

申请人： Fred Reichert ,  Keith Bauer ,  Thomas W. Myers

发明人： Fred Reichert ,  Keith Bauer ,  Thomas W. Myers

IPC分类号： C12N9/00 ,  C12N15/54

CPC分类号： C12N9/1252 ,  C12P19/34 ,  C12Q1/6858 ,  C12Q1/686 ,  C12Y207/07007 ,  C12Q2521/101

摘要： Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.

公开(公告)号：US08502026B2

公开(公告)日：2013-08-06

申请号：US12860188

申请日：2010-08-20

申请人： Maureen Daley ,  Jason Fenner ,  Beth Savidge ,  Dale Val ,  Wei Zheng

发明人： Maureen Daley ,  Jason Fenner ,  Beth Savidge ,  Dale Val ,  Wei Zheng

IPC分类号： C12N15/52 ,  C12N15/54 ,  C12N15/82 ,  C12N5/10 ,  C12N1/13 ,  A01H5/00 ,  A01H5/10 ,  A01H13/00

CPC分类号： C12N15/8261 ,  C11B1/00 ,  C12N15/8218 ,  C12N15/8243 ,  Y02A40/146

摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein, enhanced seed oil and modified oil composition. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced traits.

摘要翻译： 本发明提供具有用于表达蛋白质的重组DNA的转基因植物细胞，其可用于赋予转基因作物植物增强的农艺性状。 本发明还提供包含转基因植物细胞的转基因植物和后代种子，其中植物被选择用于具有增强的性状，所述性状选自由增强的水利用效率，增强的耐寒性，增加的产量，增强的氮利用效率，增强的氮利用效率， 种子蛋白，增强种子油和改性油组成。 还公开了用于制备具有增强特征的转基因种子和植物的方法。

公开(公告)号：US08476023B2

公开(公告)日：2013-07-02

申请号：US12852957

申请日：2010-08-09

申请人： Philip Lazarus ,  Dongxiao Sun

发明人： Philip Lazarus ,  Dongxiao Sun

IPC分类号： C12Q1/68 ,  C12N15/54 ,  C12N15/52

CPC分类号： C12Q1/6883 ,  C12Q1/48 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N2333/91097 ,  Y10T436/143333

摘要： Methods for aiding in determining therapeutic efficacy of an aromatase inhibitor in a subject are provided according to embodiments of the present invention which include detecting expression and/or function of at least one UDP-glucuronosyltransferase having activity to modify at least one aromatase inhibitor and/or metabolite of the aromatase inhibitor by glucuronidation, wherein detection of expression and/or function of the UDP-glucuronosyltransferase is correlated with therapeutic efficacy of the aromatase inhibitor in the subject. Detection of UDP-glucuronosyltransferase expression and/or function includes detection of a UDP-glucuronosyltransferase gene deletion polymorphism in the subject.

摘要翻译： 根据本发明的实施方案提供帮助确定受试者中芳香酶抑制剂的治疗功效的方法，其包括检测至少一种UDP-葡糖醛酸基转移酶的表达和/或功能，其具有修饰至少一种芳香酶抑制剂和/或 芳香酶抑制剂通过葡糖苷酸化的代谢物，其中UDP-葡糖醛酸基转移酶的表达和/或功能的检测与芳香酶抑制剂在受试者中的治疗功效相关。 UDP-葡糖醛酸基转移酶表达和/或功能的检测包括检测受试者中UDP-葡糖醛酸基转移酶基因缺失多态性。

公开(公告)号：US20130040348A1

公开(公告)日：2013-02-14

申请号：US13642911

申请日：2010-05-13

申请人： Eiichiro Ono ,  Toshiaki Umezawa ,  Takefumi Hattori ,  Shiro Suzuki

发明人： Eiichiro Ono ,  Toshiaki Umezawa ,  Takefumi Hattori ,  Shiro Suzuki

IPC分类号： C12N9/10 ,  C12N15/63 ,  A01K67/00 ,  A01K67/033 ,  A01H5/00 ,  C12N15/54 ,  C12P17/04

CPC分类号： C12N9/1007 ,  C12N15/8243 ,  C12N15/8255 ,  C12P17/181

摘要： The present invention provides an enzyme having an activity of transferring a methyl group to lignans (a lignan methylation activity) (e.g., a protein comprising the amino acid sequence of SEQ ID NO:2 or variants thereof); a gene encoding the enzyme (e.g., a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 or variants thereof); a method for producing methylated lignans using the gene; and so on.

摘要翻译： 本发明提供了具有将甲基转移到木脂体（木质素甲基化活性）（例如包含SEQ ID NO：2的氨基酸序列的蛋白质或其变体）的活性的酶）。 编码该酶的基因（例如，包含SEQ ID NO：1的核苷酸序列的多核苷酸或其变体）; 使用该基因生产甲基化木脂素的方法; 等等。