发明授权
US08476289B2 Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylace
有权
氮杂双环己基取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰基的新型抑制剂
- 专利标题： Aza-bicyclohexyl substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylace
- 专利标题（中）： 氮杂双环己基取代的吲哚基烷基氨基衍生物作为组蛋白脱乙酰基的新型抑制剂
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申请号： US12934894申请日： 2009-03-26
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公开(公告)号： US08476289B2公开(公告)日： 2013-07-02
- 发明人: Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Patrick René Angibaud
- 申请人： Eddy Jean Edgard Freyne , Isabelle Noëlle Constance Pilatte , Patrick René Angibaud
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica NV
- 当前专利权人： Janssen Pharmaceutica NV
- 当前专利权人地址： BE Beerse
- 优先权： EP08153370 20080327
- 国际申请： PCT/EP2009/053566 WO 20090326
- 国际公布： WO2009/118370 WO 20091001
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; A61K31/506
摘要：
This invention comprises the novel compounds of formula (I) wherein R1, R2, R3, R4, A and X have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
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