- 专利标题： Methods and compositions for modulating P300/CBP activity
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申请号： US12665751申请日： 2008-06-19
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公开(公告)号： US08476458B2公开(公告)日： 2013-07-02
- 发明人: Ronen Marmorstein , Xin Liu , Philip A. Cole , Ling Wang , Erin M. Bowers , David J. Meyers , Chandrani Mukherjee
- 申请人： Ronen Marmorstein , Xin Liu , Philip A. Cole , Ling Wang , Erin M. Bowers , David J. Meyers , Chandrani Mukherjee
- 申请人地址： US PA Philadelphia US MD Baltimore
- 专利权人： The Wistar Institute,The John Hopkins University
- 当前专利权人： The Wistar Institute,The John Hopkins University
- 当前专利权人地址： US PA Philadelphia US MD Baltimore
- 代理机构： Licata & Tyrrell P.C.
- 国际申请： PCT/US2008/067477 WO 20080619
- 国际公布： WO2008/157680 WO 20081224
- 主分类号： C07D231/00
- IPC分类号： C07D231/00 ; C07D231/06 ; C07D307/00 ; C07D317/00 ; C07D323/02
摘要：
The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.
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