Systems and techniques relating to interpreting signals on a channel having an asymmetrical signal amplitude response are described. A described system includes an asymmetry correction circuit configured to receive an analog signal and to compensate for asymmetry in the received analog signal, a signal equalizer configured to receive an input signal responsive to an output of the asymmetry correction circuit and to generate an equalized signal, a discrete time sequence detector operable to examine the equalized signal, and a control circuit operable to provide a coefficient adjustment to the asymmetry correction circuit to affect asymmetry compensation based on an estimate of nonlinearity derived from the equalized signal and multiple reconstructed ideal channel output values. The reconstructed ideal channel output values can be derived from an output of the discrete time sequence detector and correspond to at least two different discrete times.