发明授权
US08487102B2 Pyrrazolopyridine compounds as dual NK1/NK3 receptor antagonists
有权
吡唑并吡啶化合物作为双重NK1 / NK3受体拮抗剂
- 专利标题： Pyrrazolopyridine compounds as dual NK1/NK3 receptor antagonists
- 专利标题（中）： 吡唑并吡啶化合物作为双重NK1 / NK3受体拮抗剂
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申请号： US13083636申请日： 2011-04-11
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公开(公告)号： US08487102B2公开(公告)日： 2013-07-16
- 发明人: Philippe Jablonski , Matthias Nettekoven , Angelique Patiny-Adam , Hasane Ratni , Heinz Stadler
- 申请人： Philippe Jablonski , Matthias Nettekoven , Angelique Patiny-Adam , Hasane Ratni , Heinz Stadler
- 申请人地址： US NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Nutley
- 优先权： EP10160481 20100420
- 主分类号： C07D471/04
- IPC分类号： C07D471/04
摘要：
The present invention relates to a compound of formula I wherein R1, R2, R3, Ar, and n are as defined herein or to a pharmaceutically active acid addition salt. Compounds of formula I show a high affinity simultaneously to both the NK1 and the NK3 receptors (dual NK1/NK3 receptor antagonists), useful in the treatment of schizophrenia.
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