Invention Grant
- Patent Title: Imaging agents for detecting neurological disorders
- Patent Title (中): 用于检测神经系统疾病的成像剂
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Application No.: US12661777Application Date: 2010-03-23
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Publication No.: US08491869B2Publication Date: 2013-07-23
- Inventor: Umesh B. Gangadharmath , Hartmuth C. Kolb , Peter J. H. Scott , Joseph C. Walsh , Wei Zhang , Anna Katrin Szardenings , Anjana Sinha , Gang Chen , Eric Wang , Vani P. Mocharia , Chul Yu , Changhui Liu , Daniel Kurt Cashion , Dhanalakshmi Kasi
- Applicant: Umesh B. Gangadharmath , Hartmuth C. Kolb , Peter J. H. Scott , Joseph C. Walsh , Wei Zhang , Anna Katrin Szardenings , Anjana Sinha , Gang Chen , Eric Wang , Vani P. Mocharia , Chul Yu , Changhui Liu , Daniel Kurt Cashion , Dhanalakshmi Kasi
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Manisha A. Desai
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14

Abstract:
Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
Public/Granted literature
- US20100239496A1 Imaging agents for detecting neurological disorders Public/Granted day:2010-09-23
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