发明授权
US08492610B1 Transgeneic animal expressing a multiple mutated form of presenilin 1
有权
表达多发性突变型早老素的转基因动物1
- 专利标题: Transgeneic animal expressing a multiple mutated form of presenilin 1
- 专利标题(中): 表达多发性突变型早老素的转基因动物1
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申请号: US10088139申请日: 2000-09-22
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公开(公告)号: US08492610B1公开(公告)日: 2013-07-23
- 发明人: Anne Eckert , Walter Muller , Christian Czech , Laurent Pradier , Gunter Tremp
- 申请人: Anne Eckert , Walter Muller , Christian Czech , Laurent Pradier , Gunter Tremp
- 申请人地址: FR Antony
- 专利权人: Aventis Pharma S.A.
- 当前专利权人: Aventis Pharma S.A.
- 当前专利权人地址: FR Antony
- 代理机构: Lathrop & Gage LLP
- 优先权: FR9912017 19990927
- 国际申请: PCT/FR00/02623 WO 20000922
- 国际公布: WO01/22811 WO 20010405
- 主分类号: G01N33/00
- IPC分类号: G01N33/00 ; A01K67/00 ; A01K67/27 ; C12N5/07
摘要:
The present invention relates to the field of transgenic animal models and more particularly the animal models of Alzheimer's disease. The invention relates to a transgenic animal expressing a multimutated form of presenilin 1 and allowing an apoptotic phenomenon to be detected in a renewable peripheral tissue.