A method of signal transmission/reception by a transmitter in a wireless mobile communication system is provided. The method includes determining a signal transmission/reception corresponding relation between a downlink and an uplink of the wireless mobile communication system using a super-frame, the super-frame including at least one frame, said at least one frame including at least one downlink sub-frame and at least one uplink sub-frame, the signal transmission/reception corresponding relation enabling each sub-frame within a link including fewer sub-frames to correspond to at least one sub-frame within a link including more sub-frames when the downlink and the uplink of the wireless mobile communication system include different numbers of sub-frames, wherein the signal transmission/reception corresponding relation is also determined when the downlink and the uplink of the wireless mobile communication system include a same number of sub-frames, and transmitting and receiving signals to and from a receiver through at least one downlink sub-frame and at least one uplink sub-frame according to the determined signal transmission/reception corresponding relation.