发明授权
US08507222B2 Multimeric IL-15 soluble fusion molecules and methods of making and using same
有权
多聚IL-15可溶性融合分子及其制备和使用方法
- 专利标题： Multimeric IL-15 soluble fusion molecules and methods of making and using same
- 专利标题（中）： 多聚IL-15可溶性融合分子及其制备和使用方法
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申请号： US13238925申请日： 2011-09-21
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公开(公告)号： US08507222B2公开(公告)日： 2013-08-13
- 发明人: Hing C. Wong , Peter Rhode , Bai Liu , Xiaoyun Zhu , Kai-ping Han
- 申请人： Hing C. Wong , Peter Rhode , Bai Liu , Xiaoyun Zhu , Kai-ping Han
- 申请人地址： US FL Miramar
- 专利权人： Altor BioScience Corporation
- 当前专利权人： Altor BioScience Corporation
- 当前专利权人地址： US FL Miramar
- 代理机构： Edwards Wildman Palmer LLP
- 代理商 Peter F. Corless
- 主分类号： C12N15/62
- IPC分类号： C12N15/62 ; C12N15/24 ; C12N5/00 ; C12P21/00 ; C07K14/54 ; C07K14/715 ; C07K14/71 ; C07H21/04
摘要：
The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.
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