发明授权
- 专利标题： Process for the preparation of rosuvastatin salts
- 专利标题（中）： 罗苏伐他汀盐的制备方法
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申请号： US13143943申请日： 2010-01-15
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公开(公告)号： US08507513B2公开(公告)日： 2013-08-13
- 发明人: Gyoergyi Kovanyine Lax , Eva Sipos , Jozsef Barkoczy , Balazs Volk , Gyula Simig , Ferenc Bartha , Gyoergy Ruzsics , Adrienn Karasz , Imre Kiraly , Kalman Nagy
- 申请人： Gyoergyi Kovanyine Lax , Eva Sipos , Jozsef Barkoczy , Balazs Volk , Gyula Simig , Ferenc Bartha , Gyoergy Ruzsics , Adrienn Karasz , Imre Kiraly , Kalman Nagy
- 申请人地址： HU Budapest
- 专利权人： Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
- 当前专利权人： Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag
- 当前专利权人地址： HU Budapest
- 代理商 Jonathan Myers; Andrew Wilford
- 优先权： HU0900019 20090115; HU0900460 20090724
- 国际申请： PCT/HU2010/000007 WO 20100115
- 国际公布： WO2010/082072 WO 20100722
- 主分类号： A01N43/54
- IPC分类号： A01N43/54 ; A61K31/505
摘要：
The present invention relates to a new process for the preparation of rosuvastatin [7-[4-(4-Fluorophenyl)-6-isopropyl-2-(methanesulphonyl-methyl-amino)-pyrimidin-5-yl]-(3R,51S)-dihydroxy-hept-6-enoic acid] of the formula (I) salts formed with bivalent cations, preferably with calcium or zinc ions, characterized in that rosuvastatin tert.-butylammonium salt is reacted with the appropriate bivalent cation, preferably with calcium or zinc ions in a mixture of a water immiscible or slightly miscible organic solvent and water and the formed salt is isolated.
公开/授权文献
- US20120116082A1 PROCESS FOR THE PREPARATION OF ROSUVASTATIN SALTS 公开/授权日：2012-05-10
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