发明授权
- 专利标题： Method for synthesis of nitroxyl radical
- 专利标题（中）： 硝酰自由基的合成方法
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申请号： US12523341申请日： 2008-01-30
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公开(公告)号： US08513417B2公开(公告)日： 2013-08-20
- 发明人: Hideo Utsumi , Kiyoshi Sakai , Kenichi Yamada
- 申请人： Hideo Utsumi , Kiyoshi Sakai , Kenichi Yamada
- 申请人地址： JP Fukuoka
- 专利权人： Kyushu University, National University Corporation
- 当前专利权人： Kyushu University, National University Corporation
- 当前专利权人地址： JP Fukuoka
- 代理机构： Ladas & Parry LLP
- 国际申请： PCT/JP2008/051899 WO 20080130
- 国际公布： WO2008/093881 WO 20080807
- 主分类号： C07D221/20
- IPC分类号： C07D221/20
摘要：
The problem to be solved by the present invention is to provide a highly-versatile method for producing a nitroxyl radical derivative, in which position-2 and position-6 in a TEMPO-based compound can be easily substituted, and further, a method for producing a nitroxyl radical derivative, in which a nitrogen nucleus is labeled with 15N. The above-described problem can be solved by reacting a triacetoneamine derivative with ketone or aldehyde in the presence of ammonium salt or a 15N-labeled compound thereof to obtain a 2,6-substituted-4-piperidone derivative.
公开/授权文献
- US20100076190A1 METHOD FOR SYNTHESIS OF NITROXYL RADICAL 公开/授权日：2010-03-25
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