公开(公告)号：US08513417B2

公开(公告)日：2013-08-20

申请号：US12523341

申请日：2008-01-30

申请人： Hideo Utsumi ,  Kiyoshi Sakai ,  Kenichi Yamada

发明人： Hideo Utsumi ,  Kiyoshi Sakai ,  Kenichi Yamada

IPC分类号： C07D221/20

CPC分类号： C07D211/74 ,  A61K49/20 ,  C07D211/94 ,  C07D221/20 ,  C07D471/10 ,  C07D471/20 ,  C07D491/20 ,  C07D495/20

摘要： The problem to be solved by the present invention is to provide a highly-versatile method for producing a nitroxyl radical derivative, in which position-2 and position-6 in a TEMPO-based compound can be easily substituted, and further, a method for producing a nitroxyl radical derivative, in which a nitrogen nucleus is labeled with 15N. The above-described problem can be solved by reacting a triacetoneamine derivative with ketone or aldehyde in the presence of ammonium salt or a 15N-labeled compound thereof to obtain a 2,6-substituted-4-piperidone derivative.

摘要翻译： 本发明要解决的问题是提供一种用于制备硝酰自由基衍生物的高通用性方法，其中TEMPO基化合物中的位置2和位置-6可以容易地被取代，此外，还提供了一种用于 产生氮氧自由基衍生物，其中氮核用15N标记。 上述问题可以通过在铵盐或其15N标记的化合物存在下使三丙酮衍生物与酮或醛反应来获得2,6-取代-4-哌啶酮衍生物来解决。

公开(公告)号：US20100076190A1

公开(公告)日：2010-03-25

申请号：US12523341

申请日：2008-01-30

申请人： Hideo Utsumi ,  Kiyoshi Sakai ,  Kenichi Yamada

发明人： Hideo Utsumi ,  Kiyoshi Sakai ,  Kenichi Yamada

IPC分类号： C07D211/74 ,  C07D491/20 ,  C07D495/20 ,  C07D471/20 ,  C07D471/10

CPC分类号： C07D211/74 ,  A61K49/20 ,  C07D211/94 ,  C07D221/20 ,  C07D471/10 ,  C07D471/20 ,  C07D491/20 ,  C07D495/20

摘要： The problem to be solved by the present invention is to provide a highly-versatile method for producing a nitroxyl radical derivative, in which position-2 and position-6 in a TEMPO-based compound can be easily substituted, and further, a method for producing a nitroxyl radical derivative, in which a nitrogen nucleus is labeled with 15N. The above-described problem can be solved by reacting a triacetoneamine derivative with ketone or aldehyde in the presence of ammonium salt or a 15N-labeled compound thereof to obtain a 2,6-substituted-4-piperidone derivative.

摘要翻译： 本发明要解决的问题是提供一种用于制备硝酰自由基衍生物的高通用性方法，其中TEMPO基化合物中的位置2和位置-6可以容易地被取代，此外，还提供了一种用于 产生氮氧自由基衍生物，其中氮核用15N标记。 上述问题可以通过在铵盐或其15N标记的化合物存在下使三丙酮衍生物与酮或醛反应来获得2,6-取代-4-哌啶酮衍生物来解决。

公开(公告)号：US20130195991A1

公开(公告)日：2013-08-01

申请号：US13637107

申请日：2011-03-25

申请人： Minoru Ueda ,  Yoichi Yamada ,  Katsumi Ebisawa ,  Akihito Yamamoto ,  Kiyoshi Sakai ,  Kohki Matsubara ,  Hisashi Hattori ,  Masahiko Sugiyama ,  Takanori Inoue

发明人： Minoru Ueda ,  Yoichi Yamada ,  Katsumi Ebisawa ,  Akihito Yamamoto ,  Kiyoshi Sakai ,  Kohki Matsubara ,  Hisashi Hattori ,  Masahiko Sugiyama ,  Takanori Inoue

IPC分类号： A61K35/12

CPC分类号： A61K35/12 ,  A61K35/28 ,  A61K35/30 ,  A61K35/32 ,  A61K35/545 ,  A61K38/18 ,  A61K38/1833 ,  A61K38/1841 ,  A61K38/1858 ,  A61K38/1866 ,  A61K38/30 ,  C12N5/0664 ,  A61K2300/00

摘要： The present invention provides a damaged part treatment composition for repairing a damaged part of a target tissue that includes a stem cell-conditioned medium obtained by culturing stem cells; a damaged part treatment method for repairing or restoring a damaged part of a target tissue that includes administering the damaged part treatment composition to a patient having the target tissue for the damaged part treatment composition in an amount therapeutically effective for repairing the damaged part of the target tissue; a method of treating cerebral infarction that includes administering the damaged part treatment composition to a cerebral infarct patient in an amount effective for repairing a damaged part of the brain; and a method of treating a CNS disease that includes administering, as a CNS disease treatment composition, the damaged part treatment composition to a CNS disease patient in a therapeutically effective amount.

摘要翻译： 本发明提供一种用于修复目标组织的损伤部分的损伤部分处理组合物，其包括通过培养干细胞获得的干细胞条件培养基; 用于修复或恢复目标组织的损伤部分的损坏部分处理方法，包括将损伤的部分处理组合物施用于具有损伤部分处理组合物的目标组织的患者，其量以治疗有效的量修复靶的损伤部分 组织; 一种治疗脑梗死的方法，其包括以有效修复脑损伤部分的量将损伤的部分治疗组合物给予脑梗死患者; 以及治疗CNS疾病的方法，其包括以治疗有效量向CNS疾病患者施用所述损伤的部分治疗组合物作为CNS疾病治疗组合物。

公开(公告)号：US20070217510A1

公开(公告)日：2007-09-20

申请号：US11460260

申请日：2006-07-27

申请人： Akihiro Yamori ,  Akira Nakagawa ,  Kiyoshi Sakai

发明人： Akihiro Yamori ,  Akira Nakagawa ,  Kiyoshi Sakai

IPC分类号： H04N7/12 ,  H04N11/04

CPC分类号： H04N19/157 ,  H04N19/109 ,  H04N19/176 ,  H04N19/52 ,  H04N19/61

摘要： The present invention provides a video coding method which includes, as one of a plurality of coding modes, a direct mode generating a piece of motion information of each of Macro Blocks, which are obtained by dividing a first picture, by predicting from motion information of a coded Macro Block of other plurality of second pictures, including: a first step for selecting the direct mode as the coding mode by using a variable selection criterion; and a second step for coding the Macro Blocks based on the selected coding mode.

摘要翻译： 本发明提供一种视频编码方法，其包括作为多个编码模式之一的直接模式，通过从第一图像的运动信息预测生成通过划分第一图像获得的每个宏块的运动信息， 其它多个第二图像的编码宏块，包括：通过使用变量选择准则来选择直接模式作为编码模式的第一步骤; 以及用于基于所选择的编码模式对宏块进行编码的第二步骤。

公开(公告)号：US06725003B2

公开(公告)日：2004-04-20

申请号：US09964584

申请日：2001-09-28

申请人： Yasuyuki Shinkai ,  Kiyoshi Sakai ,  Satoru Tomita ,  Mamoru Kiyota ,  Kohji Ichimiya ,  Yuichiro Kanoshima ,  Nekka Matsuura

发明人： Yasuyuki Shinkai ,  Kiyoshi Sakai ,  Satoru Tomita ,  Mamoru Kiyota ,  Kohji Ichimiya ,  Yuichiro Kanoshima ,  Nekka Matsuura

IPC分类号： G03G1500

CPC分类号： G03G21/1619 ,  G03G15/0194 ,  G03G2221/1684

摘要： An image forming apparatus including a plurality of imaging units each for forming an image on a recording medium, an image carrier provided in each of the plurality of imaging unit, a development unit for visualizing an electrostatic latent image on the image carrier by toner in each of the plurality of imaging units, and a supporting device configured to integrate at least two imaging units of the plurality of imaging units into a unit, wherein the supporting device has a plurality of pressing members configured to press upper portions of the at least two imaging units, respectively, and a plurality of supporting members configured to support lower portions of the at least two imagining units, respectively.

摘要翻译： 一种图像形成装置，包括：用于在记录介质上形成图像的多个成像单元;设置在所述多个成像单元中的每一个中的图像载体;显影单元，用于通过各自中的调色剂使所述图像载体上的静电潜像可视化 以及支撑装置，其被配置为将所述多个成像单元中的至少两个成像单元集成为一个单元，其中所述支撑装置具有多个按压构件，所述多个按压构件构造成按压所述至少两个成像的上部 以及分别配置成支撑所述至少两个想象单元的下部的多个支撑构件。

公开(公告)号：US06207151B1

公开(公告)日：2001-03-27

申请号：US08259152

申请日：1994-06-13

申请人： Yukio Shimazaki ,  Nobuhiro Kawashima ,  Miki Suzuki ,  Yasuhito Tanaka ,  Ryo Tanaka ,  Kiyoshi Sakai ,  Hisahiro Ishiwari

发明人： Yukio Shimazaki ,  Nobuhiro Kawashima ,  Miki Suzuki ,  Yasuhito Tanaka ,  Ryo Tanaka ,  Kiyoshi Sakai ,  Hisahiro Ishiwari

IPC分类号： A61K3849

CPC分类号： A61K38/49 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42

摘要： Aqueous protein-containing solutions, in which a protein is dissolved at a high concentration at a pH near the isoelectric point of the protein by adding an anionic polymer or a salt thereof to the solution. Pharmaceutical formulations using a physiologically active protein are prepared using this technique.

摘要翻译： 含有蛋白质的溶液，其中蛋白质通过向溶液中加入阴离子聚合物或其盐，在接近蛋白质等电点的pH下以高浓度溶解。 使用该技术制备使用生理活性蛋白质的药物制剂。

公开(公告)号：US5844611A

公开(公告)日：1998-12-01

申请号：US452834

申请日：1995-05-30

申请人： Takashi Hamano ,  Kiyoshi Sakai ,  Kiichi Matsuda

发明人： Takashi Hamano ,  Kiyoshi Sakai ,  Kiichi Matsuda

IPC分类号： G06T9/00 ,  H03M7/42 ,  H04N19/126 ,  H04N19/136 ,  H04N19/152 ,  H04N19/196 ,  H04N19/42 ,  H04N19/423 ,  H04N19/50 ,  H04N19/503 ,  H04N19/60 ,  H04N19/61 ,  H04N19/625 ,  H04N19/85 ,  H04N19/91 ,  H04N7/30

CPC分类号： H04N19/00 ,  H03M7/42 ,  H04N19/124 ,  H04N19/152 ,  H04N19/176 ,  H04N19/60 ,  H04N19/61 ,  H04N19/13 ,  H04N19/146 ,  H04N19/50 ,  H04N19/91

摘要： An image encoding control system includes an orthogonal transform encoder for carrying out orthogonal transform coding for each block which includes transform coefficients related to a plurality of blocks, each block obtained by dividing one picture of an input image signal into the plurality of blocks, a code control for controlling the transform coefficients obtained for each block so that the number of variable-length code words obtained for each block is equal to or smaller than a predetermined number of variable-length code words, a variable-length encoder for converting the transform coefficients obtained for each block into variable-length code words, and a buffer memory for temporarily storing the variable-length code words output by the variable-length encoder for each block.

摘要翻译： 图像编码控制系统包括正交变换编码器，用于对包括与多个块相关的变换系数的每个块执行正交变换编码，每个块通过将输入图像信号的一个图像分成多个块而获得;块 用于控制为每个块获得的变换系数，使得为每个块获得的可变长度码字的数量等于或小于预定数量的可变长度码字;可变长度编码器，用于将变换系数 对于每个块获得的可变长度码字;以及缓冲存储器，用于临时存储由每个块由可变长度编码器输出的可变长度码字。

公开(公告)号：US5719963A

公开(公告)日：1998-02-17

申请号：US454867

申请日：1995-05-31

申请人： Kimihiko Kazui ,  Kiyoshi Sakai ,  Kiichi Matsuda ,  Akira Nakagawa

发明人： Kimihiko Kazui ,  Kiyoshi Sakai ,  Kiichi Matsuda ,  Akira Nakagawa

IPC分类号： H04N7/30 ,  G06F17/14 ,  G06T1/20 ,  G06T9/00 ,  H03M7/30 ,  H04N1/41 ,  G06K9/20 ,  G06F15/00 ,  G06K9/38

CPC分类号： G06F17/147 ,  G06T9/007

摘要： A two-dimensional discrete cosine transform computing circuit has a transform block, formed by a multiplication unit and a Hadamard transform unit, which performs computations in a sequence of Hadamard transforms followed by multiplications in a two-dimensional discrete cosine transform, and in a sequence of multiplication followed by Hadamard transforms in an inverse two-dimensional discrete cosine transform. A memory block temporarily stores input/output data of the transform block; an input/output processing block performs pre-processing and post-processing such as cumulative addition and subtraction of input/output data of the transform block. A control block controls, when performing processing for either a two-dimensional discrete cosine transform or inverse two-dimensional discrete cosine transform, multiplications of coefficients in the transform block, read/write of the memory block, and the input/output processing block. This configuration achieves high-speed processing and a reduction in scale of the circuitry.

摘要翻译： 二维离散余弦变换计算电路具有由乘法单元和Hadamard变换单元形成的变换块，该单元在Hadamard变换序列中进行计算，随后在二维离散余弦变换中进行乘法，并以序列 的乘法，然后是逆二维离散余弦变换中的Hadamard变换。 存储块临时存储变换块的输入/输出数据; 输入/输出处理块执行诸如变换块的输入/输出数据的累积加法和减法的预处理和后处理。 当执行二维离散余弦变换或反向二维离散余弦变换的处理时，控制块控制变换块中的系数乘法，存储块的读/写和输入/输出处理块。 该配置实现了高速处理和电路规模的缩小。

公开(公告)号：US5534581A

公开(公告)日：1996-07-09

申请号：US395185

申请日：1995-02-27

申请人： Noriko Ohtani ,  Naoto Fujimura ,  Kiyoshi Sakai ,  Teigo Sakakibara ,  Masahiro Inoue ,  Nobuhiko Takekoshi ,  Shinya Mayama ,  Hideo Ohtaki ,  Tadami Kinugawa ,  Toshiaki Takada ,  Yuichi Hashimoto

发明人： Noriko Ohtani ,  Naoto Fujimura ,  Kiyoshi Sakai ,  Teigo Sakakibara ,  Masahiro Inoue ,  Nobuhiko Takekoshi ,  Shinya Mayama ,  Hideo Ohtaki ,  Tadami Kinugawa ,  Toshiaki Takada ,  Yuichi Hashimoto

IPC分类号： G03G7/00 ,  G03G15/16 ,  C08K3/04 ,  C08K3/22 ,  H01B1/20 ,  H01B1/24

CPC分类号： G03G15/1655 ,  G03G7/0066 ,  G03G7/008

摘要： A transfer material carrying member has a copolymer and conductive particles; the copolymer has a component unit represented by the Formula (I) and a component unit represented by the Formula (II), and the component unit represented by Formula (II) is in an amount of from 0.1% by weight to 50% by weight based on the total weight of the copolymer.

摘要翻译： 转印材料承载构件具有共聚物和导电颗粒; 该共聚物具有由式（I）表示的组分单元和由式（II）表示的组分单元，式（II）表示的组分单元的量为0.1重量％至50重量％ 基于共聚物的总重量。

公开(公告)号：US5320922A

公开(公告)日：1994-06-14

申请号：US945379

申请日：1992-09-16

申请人： Shinya Mayama ,  Kiyoshi Sakai

发明人： Shinya Mayama ,  Kiyoshi Sakai

IPC分类号： G03G5/14

CPC分类号： G03G5/144

摘要： An electrophotographic photosensitive medium has a photosensitive layer on an electroconductive base, the medium having at least one intermediate layer between the base and the photosensitive layer, the intermediate layer containing indium oxide - tin oxide solid solution (ITO) powder and a binder resin. An electrophotographic apparatus includes a photosensitive medium; a device for forming latent images; a device for developing formed latent images; and a device for transferring developed images to a transfer member.

摘要翻译： 电子照相感光性介质在导电性基体上具有感光层，介质在基材和感光层之间具有至少一个中间层，中间层含有氧化铟 - 氧化锡固溶体（ITO）粉末和粘合剂树脂。 电子照相设备包括光敏介质; 用于形成潜像的装置; 用于显影形成的潜像的装置; 以及用于将显影图像转印到转印部件的装置。