Invention Grant
- Patent Title: Process for the preparation of pyrazole carboxylic acid amides
- Patent Title (中): 制备吡唑羧酸酰胺的方法
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Application No.: US13642406Application Date: 2011-04-14
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Publication No.: US08519152B2Publication Date: 2013-08-27
- Inventor: Raphael Dumeunier , Florian Schleth , Thomas Vettiger , Michael Rommel , Stephan Trah
- Applicant: Raphael Dumeunier , Florian Schleth , Thomas Vettiger , Michael Rommel , Stephan Trah
- Applicant Address: US NC Greensboro
- Assignee: Syngenta Crop Protection LLC
- Current Assignee: Syngenta Crop Protection LLC
- Current Assignee Address: US NC Greensboro
- Agent R. Kody Jones
- Priority: EP10160438 20100420
- International Application: PCT/EP2011/055871 WO 20110414
- International Announcement: WO2011/131545 WO 20111027
- Main IPC: C07D231/10
- IPC: C07D231/10 ; C07D303/02 ; C07C33/00

Abstract:
The invention relates to a process for the preparation of the compound of formula (I), which process comprises a) reacting a compound of formula (II), wherein X is chloro or bromo, with an organometallic species in an inert atmosphere to a halobenzyne of formula (X), reacting the halobenzyne of formula X so formed with cyclopentadiene to (III), b) reacting III in the presence of an inert solvent with an oxidant to (IV), c) reacting IV in the presence of a Lewis acid and a hydride source to (V), d) reacting V in the presence of an oxidizing agent, a base and an inert solvent to (VI), e) converting VI in the presence of a phosphane and CCl4 or CHCl3 to (VII), and either f1) reacting VII with NH3 in the presence of a catalyst to the compound of formula (VIII); and g) reacting VIII in the presence of a base with a compound of formula (IX), to the compound of formula (I); or f2) reacting the compound of formula (VII), in the presence of a solvent, a base, a copper catalyst and at least one ligand with the compound of formula (IXa), to the compound of formula (I).
Public/Granted literature
- US20130035496A1 PROCESS FOR THE PREPARATION OF PYRAZOLE CARBOXYLIC ACID AMIDES Public/Granted day:2013-02-07
Information query