发明授权
- 专利标题: Spirochromanone carboxylic acids
- 专利标题(中): 新型螺环酮羧酸
-
申请号: US12997263申请日: 2009-06-29
-
公开(公告)号: US08524730B2公开(公告)日: 2013-09-03
- 发明人: Hideki Jona , Yoshihiro Shibata , Takeru Yamakawa
- 申请人: Hideki Jona , Yoshihiro Shibata , Takeru Yamakawa
- 申请人地址: JP Tokyo
- 专利权人: MSD K.K.
- 当前专利权人: MSD K.K.
- 当前专利权人地址: JP Tokyo
- 代理商 Janet E. Fair; John C. Todaro
- 优先权: JP2008-175229 20080704; JP2009-108704 20090428
- 国际申请: PCT/JP2009/062237 WO 20090629
- 国际公布: WO2010/002010 WO 20100107
- 主分类号: C07D405/04
- IPC分类号: C07D405/04 ; A61K31/438
摘要:
The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar1 represents a group formed from an aromatic ring; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
公开/授权文献
- US20110077262A1 NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS 公开/授权日:2011-03-31
信息查询