发明授权
US08524730B2 Spirochromanone carboxylic acids 有权
新型螺环酮羧酸

  • 专利标题: Spirochromanone carboxylic acids
  • 专利标题(中): 新型螺环酮羧酸
  • 申请号: US12997263
    申请日: 2009-06-29
  • 公开(公告)号: US08524730B2
    公开(公告)日: 2013-09-03
  • 发明人: Hideki JonaYoshihiro ShibataTakeru Yamakawa
  • 申请人: Hideki JonaYoshihiro ShibataTakeru Yamakawa
  • 申请人地址: JP Tokyo
  • 专利权人: MSD K.K.
  • 当前专利权人: MSD K.K.
  • 当前专利权人地址: JP Tokyo
  • 代理商 Janet E. Fair; John C. Todaro
  • 优先权: JP2008-175229 20080704; JP2009-108704 20090428
  • 国际申请: PCT/JP2009/062237 WO 20090629
  • 国际公布: WO2010/002010 WO 20100107
  • 主分类号: C07D405/04
  • IPC分类号: C07D405/04 A61K31/438
Spirochromanone carboxylic acids
摘要:
The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar1 represents a group formed from an aromatic ring; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
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