发明授权
US08530650B2 2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer
有权
2,5-二氨基取代的吡啶并[4,3-D]嘧啶作为抗癌药的自分泌抑素
![2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer](/docs/US/2013-09-10/US08530650B2/abs.jpg.600x600.jpg)
- 专利标题： 2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer
- 专利标题（中）： 2,5-二氨基取代的吡啶并[4,3-D]嘧啶作为抗癌药的自分泌抑素
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申请号： US13132181申请日： 2009-11-03
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公开(公告)号： US08530650B2公开(公告)日： 2013-09-10
- 发明人: Kai Schiemann , Melanie Schultz , Wolfgang Staehle , Ingo Kober , Dirk Wienke , Mireille Krier
- 申请人： Kai Schiemann , Melanie Schultz , Wolfgang Staehle , Ingo Kober , Dirk Wienke , Mireille Krier
- 申请人地址： DE Darmstadt
- 专利权人： MERCK PATENT GmbH
- 当前专利权人： MERCK PATENT GmbH
- 当前专利权人地址： DE Darmstadt
- 代理机构： Millen, White, Zelano & Branigan, P.C.
- 优先权： EP08020824 20081201
- 国际申请： PCT/EP2009/007876 WO 20091103
- 国际公布： WO2010/063352 WO 20100610
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/5025
![2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer](/abs-image/US/2013/09/10/US08530650B2/abs.jpg.150x150.jpg)
摘要：
The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.