A system for guidance and navigation in a building. For example, the system may determine a route for egress or rescue of one or more people from a building with a hazardous condition. The system may process the route into waypoints and segments developed within a set of constraint rules. Semantic information about the building may be associated with the waypoints and/or segments. The waypoints and segments may be processed into navigation commands. The navigation commands may be formed in natural language from sentence templates. The system may additionally have 3D beacon audio to assist in guidance and navigation of the one or more people in the building.