A modular electronic biosensor includes a housing configured for hand-held manipulation and a base module comprising a module interface configured to receive one of a multiplicity of disparate detachable modules, such as a transducer module and an output module. A transducer of the transducer module is configured to sense a property of the human body and the output module is configured to output a signal comprising transducer signal information. The module interface includes a module connector for receiving a connector of the detachable module to facilitate signal transmission therebetween, a mechanical retention mechanism configured to retentively engage the detachable module, and a sealing arrangement disposed to provide sealing between the base module and the detachable module when attached to the base module. A processor is coupled to the module connector and configured to communicatively couple with each of the detachable and interchangeable modules when attached to the base module.