Invention Grant
- Patent Title: Process for the preparation of d-threo-ritalinic acid hydrochloride by resolution of dl-threo-ritalinic acid using chiral carboxylic acid
- Patent Title (中): 通过使用手性羧酸拆分dl-苏氨酸，制备d-苏氨酸盐酸盐的方法
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Application No.: US13055472Application Date: 2009-07-03
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Publication No.: US08552030B2Publication Date: 2013-10-08
- Inventor: Tangirala Prakasam , Borkatte Narasimha Hitesh Kumar , Sangu Perumal , Kothandapani Loganathan
- Applicant: Tangirala Prakasam , Borkatte Narasimha Hitesh Kumar , Sangu Perumal , Kothandapani Loganathan
- Applicant Address: IN Chennai
- Assignee: Malladi Drugs & Pharmaceuticals Ltd.
- Current Assignee: Malladi Drugs & Pharmaceuticals Ltd.
- Current Assignee Address: IN Chennai
- Agency: Kamrath IP Lawfirm, P.A.
- Agent Alan Kamrath
- Priority: IN1062/CHE/2009 20090507
- International Application: PCT/IN2009/000378 WO 20090703
- International Announcement: WO2010/128517 WO 20101111
- Main IPC: A61K31/445
- IPC: A61K31/445
Abstract:
The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-ritalinic acid using a chiral carboxylic acid The d-threo-ritalinic acid hydrochloride prepared by the process of the present invention on esterification gives d-threo-methylphenidate, a very well known CNS stimulant.
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