Invention Grant
US08552186B2 Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors
有权
2,4-二氨基嘧啶作为ALK和c-MET抑制剂的稠合双环衍生物
- Patent Title: Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-MET inhibitors
- Patent Title (中): 2,4-二氨基嘧啶作为ALK和c-MET抑制剂的稠合双环衍生物
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Application No.: US13413322Application Date: 2012-03-06
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Publication No.: US08552186B2Publication Date: 2013-10-08
- Inventor: Gulzar Ahmed , Henry J. Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce D. Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph Lisko , Rong-qiang Liu , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
- Applicant: Gulzar Ahmed , Henry J. Breslin , Jason Burke , Matthew A. Curry , James L. Diebold , Bruce D. Dorsey , Benjamin J. Dugan , Daming Feng , Diane E. Gingrich , Tao Guo , Keith S. Learn , Joseph Lisko , Rong-qiang Liu , Eugen F. Mesaros , Karen L. Milkiewicz , Gregory R. Ott , Jay P. Theroff , Tho Thieu , Rabindranath Tripathy , Theodore L. Underiner , Gregory J. Wells , Craig A. Zificsak
- Applicant Address: US PA Frazier
- Assignee: Cephalon, Inc.
- Current Assignee: Cephalon, Inc.
- Current Assignee Address: US PA Frazier
- Main IPC: C07D403/12
- IPC: C07D403/12
Abstract:
The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
Public/Granted literature
- US20120165519A1 Fused Bicyclic Derivatives of 2,4-Diaminopyrimidine as ALK and c-MET Inhibitors Public/Granted day:2012-06-28
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