Invention Grant
US08557549B2 Microorganism producing O-phosphoserine and method of producing L-cysteine or derivatives thereof from O-phosphoserine using the same
有权
生产O-磷酸丝氨酸的微生物及使用其制备O-磷酸丝氨酸的L-半胱氨酸或其衍生物的方法
- Patent Title: Microorganism producing O-phosphoserine and method of producing L-cysteine or derivatives thereof from O-phosphoserine using the same
- Patent Title (中): 生产O-磷酸丝氨酸的微生物及使用其制备O-磷酸丝氨酸的L-半胱氨酸或其衍生物的方法
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Application No.: US13278105Application Date: 2011-10-20
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Publication No.: US08557549B2Publication Date: 2013-10-15
- Inventor: Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim
- Applicant: Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim
- Applicant Address: KR Seoul
- Assignee: CJ Cheildjedang Corporation
- Current Assignee: CJ Cheildjedang Corporation
- Current Assignee Address: KR Seoul
- Agency: Cooley LLP
- Priority: KR10-2010-0102664 20101020; KR10-2011-0086081 20110826
- Main IPC: C12P13/12
- IPC: C12P13/12
Abstract:
The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein.
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