- 专利标题： Spatially-defined macrocycles incorporating peptide bond surrogates
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申请号： US12471978申请日： 2009-05-26
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公开(公告)号： US08557765B2公开(公告)日： 2013-10-15
- 发明人: Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gérald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark L. Peterson , Hamid R. Hoveyda , Sylvie Beaubien , Éric Marsault , Graeme L. Fraser
- 申请人： Pierre Deslongchamps , Yves Dory , Luc Ouellet , Gérald Villeneuve , Mahesh Ramaseshan , Daniel Fortin , Mark L. Peterson , Hamid R. Hoveyda , Sylvie Beaubien , Éric Marsault , Graeme L. Fraser
- 申请人地址： CA Quebec
- 专利权人： Tranzyme Pharma Inc.
- 当前专利权人： Tranzyme Pharma Inc.
- 当前专利权人地址： CA Quebec
- 代理机构： Myers Bigel Sibley & Sajovec P.A.
- 主分类号： A61P3/04
- IPC分类号： A61P3/04
摘要：
Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.